Vittorio Porciatti

TL;DR: It is proposed that BDNF promotes the maturation of cortical inhibition during early postnatal life, thereby regulating the critical period for visual cortical plasticity.

TL;DR: Using BAX-deficient DBA/2J mice, which retain all of their RGCs, this work provides experimental evidence for an insult within or very close to the lamina in the optic nerve, and shows that proximal axon segments attached to their cell bodies survive to the proximity of theLamina.

TL;DR: Studying glaucoma-prone mice, it is shown that mitochondrial abnormalities are an early driver of neuronal dysfunction, occurring before detectable degeneration, and this supports therapeutic use of vitamin B3 in glau coma and potentially other age-related neurodegenerations.

TL;DR: The data point out the necessity to prove integrity of the inner retina before attempting restoring visual function through photoreceptor intervention, even more important when considering that although intervention can be performed before the onset of any symptoms in animals carrying inherited retinopathies, this is obviously not true for human subjects.

TL;DR: Findings corroborate recent evidence from studies on the cat, showing that the ERG in response to alternating gratings is correlated with ganglion cell activity.