V
Vivek K. Rajwanshi
Researcher at University of Copenhagen
Publications - 22
Citations - 2829
Vivek K. Rajwanshi is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Locked nucleic acid & Nucleic acid. The author has an hindex of 14, co-authored 18 publications receiving 2725 citations.
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Journal ArticleDOI
LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition
Alexei A. Koshkin,Sanjay K. Singh,Poul Nielsen,Vivek K. Rajwanshi,Ravindra Kumar,Michael Meldgaard,Carl Erik Olsen,Jesper Wengel +7 more
TL;DR: Studies of mis-matched sequences show that LNA obey the Watson-Crick base pairing rules with generally improved selectivities compared to the corresponding unmodified reference strands.
Journal ArticleDOI
LNA (Locked Nucleic Acid): An RNA Mimic Forming Exceedingly Stable LNA:LNA Duplexes
Alexei A. Koshkin,Poul Nielsen,Michael Meldgaard,Vivek K. Rajwanshi,Sanjay K. Singh,Jesper Wengel +5 more
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The first analogues of LNA (locked nucleic acids): phosphorothioate-LNA and 2'-thio-LNA.
Ravindra Kumar,Sanjay K. Singh,Alexei A. Koshkin,Vivek K. Rajwanshi,Michael Meldgaard,Jesper Wengel +5 more
TL;DR: A 9-mer phosphorothioate-LNA containing three LNA thymine monomers were able to recognize both complementary DNA and RNA with thermal affinities comparable to those of parent LNA.
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The conformations of locked nucleic acids (LNA).
Michael B. Petersen,Christina B. Nielsen,Katrine E. Nielsen,Gitte A. Jensen,Kent Bondensgaard,Sanjay K. Singh,Vivek K. Rajwanshi,Alexei A. Koshkin,Britta M. Dahl,Jesper Wengel,Jens Peter Jacobsen +10 more
TL;DR: It is proposed that the exceptional stability of the LNA modified duplexes is caused by a quenching of concerted local backbone motions by the L NA nucleotides in ssLNA so as to decrease the entropy loss on duplex formation combined with a more efficient stacking of the nucleobases.
Journal ArticleDOI
Structural studies of LNA:RNA duplexes by NMR: conformations and implications for RNase H activity.
Kent Bondensgaard,Michael Nebeling Petersen,Sanjay K. Singh,Vivek K. Rajwanshi,Ravindra Kumar,Jesper Wengel,Jens Peter Jacobsen +6 more
TL;DR: Partly modified LNA:RNA duplexes may adopt a duplex structure between the standard A and B types, thereby making the RNA strand amenable to RNase H-mediated degradation.