R
Ravindra Kumar
Researcher at Indian Council of Medical Research
Publications - 300
Citations - 10572
Ravindra Kumar is an academic researcher from Indian Council of Medical Research. The author has contributed to research in topics: Biology & Locked nucleic acid. The author has an hindex of 50, co-authored 256 publications receiving 9381 citations. Previous affiliations of Ravindra Kumar include University of Southampton & University of Delhi.
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Journal ArticleDOI
LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition
Alexei A. Koshkin,Sanjay K. Singh,Poul Nielsen,Vivek K. Rajwanshi,Ravindra Kumar,Michael Meldgaard,Carl Erik Olsen,Jesper Wengel +7 more
TL;DR: Studies of mis-matched sequences show that LNA obey the Watson-Crick base pairing rules with generally improved selectivities compared to the corresponding unmodified reference strands.
Journal ArticleDOI
Tannins: their adverse role in ruminant nutrition
Ravindra Kumar,Manohar Singh +1 more
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The first analogues of LNA (locked nucleic acids): phosphorothioate-LNA and 2'-thio-LNA.
Ravindra Kumar,Sanjay K. Singh,Alexei A. Koshkin,Vivek K. Rajwanshi,Michael Meldgaard,Jesper Wengel +5 more
TL;DR: A 9-mer phosphorothioate-LNA containing three LNA thymine monomers were able to recognize both complementary DNA and RNA with thermal affinities comparable to those of parent LNA.
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Transforming growth factor-β superfamily ligand trap ACE-536 corrects anemia by promoting late-stage erythropoiesis
Rajasekhar N V S Suragani,Samuel M. Cadena,Sharon M Cawley,Sako Dianne S,Dianne C. Mitchell,Robert Li,Monique V. Davies,Mark J. Alexander,Matthew T. Devine,Kenneth S Loveday,Kathryn W. Underwood,Asya Grinberg,John D Quisel,Rajesh Chopra,R. Scott Pearsall,Jasbir Seehra,Ravindra Kumar +16 more
TL;DR: Analysis of regulation of erythropoiesis using a ligand-trapping fusion protein containing the extracellular domain of human activin receptor type IIB modified to reduce activin binding implicate transforming growth factor-β (TGF-β) superfamily signaling in erythroid maturation and identify ACE-536 as a new potential treatment for anemia.
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Template-directed oligonucleotide strand ligation, covalent intramolecular DNA circularization and catenation using click chemistry.
TL;DR: A template-free click-ligation reaction has been used for the intramolecular circularization of a single stranded oligonucleotide which was used as a template for the synthesis of a covalently closed DNA catenane.