T
Tanya L. Daigle
Researcher at Allen Institute for Brain Science
Publications - 65
Citations - 5714
Tanya L. Daigle is an academic researcher from Allen Institute for Brain Science. The author has contributed to research in topics: Visual cortex & Neocortex. The author has an hindex of 25, co-authored 61 publications receiving 3372 citations. Previous affiliations of Tanya L. Daigle include Allen Institute for Artificial Intelligence & Université de Moncton.
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Journal ArticleDOI
Shared and distinct transcriptomic cell types across neocortical areas
Bosiljka Tasic,Zizhen Yao,Lucas T. Graybuck,Kimberly A. Smith,Thuc Nghi Nguyen,Darren Bertagnolli,Jeff Goldy,Emma Garren,Michael N. Economo,Sarada Viswanathan,Osnat Penn,Trygve E. Bakken,Vilas Menon,Vilas Menon,Jeremy A. Miller,Olivia Fong,Karla E. Hirokawa,Kanan Lathia,Christine Rimorin,Michael Tieu,Rachael Larsen,Tamara Casper,Eliza Barkan,Matthew Kroll,Sheana Parry,Nadiya V. Shapovalova,Daniel Hirschstein,Julie Pendergraft,Heather A. Sullivan,Tae Kyung Kim,Aaron Szafer,Nick Dee,Peter A. Groblewski,Ian R. Wickersham,Ali Cetin,Julie A. Harris,Boaz P. Levi,Susan M. Sunkin,Linda Madisen,Tanya L. Daigle,Loren L. Looger,Amy Bernard,John W. Phillips,Ed S. Lein,Michael Hawrylycz,Karel Svoboda,Allan R. Jones,Christof Koch,Hongkui Zeng +48 more
TL;DR: This study establishes a combined transcriptomic and projectional taxonomy of cortical cell types from functionally distinct areas of the adult mouse cortex and identifies 133 transcriptomic types of glutamatergic neurons to their long-range projection specificity.
Book ChapterDOI
Acute Brain Slice Methods for Adult and Aging Animals: Application of Targeted Patch Clamp Analysis and Optogenetics
TL;DR: This chapter describes a robust and practical protocol for preparing brain slices from mature adult mice that are suitable for patch clamp analysis and describes the application of this adult brain slice platform and associated methods for screening kinetic properties of Channelrhodopsin variants expressed in genetically defined neuronal subtypes.
Journal ArticleDOI
A Suite of Transgenic Driver and Reporter Mouse Lines with Enhanced Brain-Cell-Type Targeting and Functionality
Tanya L. Daigle,Linda Madisen,Travis A. Hage,Matthew T. Valley,Ulf Knoblich,Rylan S. Larsen,Marc Takeno,Lawrence Huang,Hong Gu,Rachael Larsen,Maya Mills,Alice Bosma-Moody,La'Akea Siverts,Miranda Walker,Lucas T. Graybuck,Zizhen Yao,Olivia Fong,Thuc Nghi Nguyen,Emma Garren,Garreck H. Lenz,Mariya Chavarha,Julie Pendergraft,James Harrington,Karla E. Hirokawa,Julie A. Harris,Philip R. Nicovich,Medea McGraw,Douglas R. Ollerenshaw,Kimberly A. Smith,Christopher A. Baker,Jonathan T. Ting,Susan M. Sunkin,Jérôme Lecoq,Michael Z. Lin,Edward S. Boyden,Gabe J. Murphy,Nuno Maçarico da Costa,Jack Waters,Lu Li,Bosiljka Tasic,Hongkui Zeng +40 more
TL;DR: A large set of driver and reporter transgenic mouse lines are reported, including 23 new driver lines targeting a variety of cortical and subcortical cell populations and 26 new reporter lines expressing an array of molecular tools.
Posted ContentDOI
Shared and distinct transcriptomic cell types across neocortical areas
Bosiljka Tasic,Zizhen Yao,Kimberly A. Smith,Lucas T. Graybuck,Thuc Nghi Nguyen,Darren Bertagnolli,Jeff Goldy,Emma Garren,Michael N. Economo,Sarada Viswanathan,Osnat Penn,Trygve E. Bakken,Vilas Menon,Jeremy A. Miller,Olivia Fong,Karla E. Hirokawa,Kanan Lathia,Christine Rimorin,Michael Tieu,Rachael Larsen,Tamara Casper,Eliza Barkan,Matthew Kroll,Seana Parry,Nadiya V. Shapovalova,Daniel Hirschstein,Julie Pendergraft,Tae Kyung Kim,Aaron Szafer,Nick Dee,Peter A. Groblewski,Ian R. Wickersham,Ali Cetin,Julie A. Harris,Boaz P. Levi,Susan M. Sunkin,Linda Madisen,Tanya L. Daigle,Loren L. Looger,Amy Bernard,John W. Phillips,Ed S. Lein,Michael Hawrylycz,Karel Svoboda,Allan R. Jones,Christof Koch,Hongkui Zeng +46 more
TL;DR: A combined transcriptomic and projectional taxonomy of cortical cell types from functionally distinct regions of the mouse cortex is established and correspondence between excitatory transcriptomic types and their region-specific long-range target specificity is demonstrated.
Journal ArticleDOI
Classification of electrophysiological and morphological neuron types in the mouse visual cortex.
Nathan W. Gouwens,Staci A. Sorensen,Jim Berg,Changkyu Lee,Tim Jarsky,Jonathan T. Ting,Susan M. Sunkin,David Feng,Costas A. Anastassiou,Eliza Barkan,Kris Bickley,Nicole Blesie,Thomas Braun,Krissy Brouner,Agata Budzillo,Shiella Caldejon,Tamara Casper,Dan Castelli,Peter Chong,Kirsten Crichton,Christine Cuhaciyan,Tanya L. Daigle,Rachel A. Dalley,Nick Dee,Tsega Desta,Songlin Ding,Samuel Dingman,Alyse Doperalski,Nadezhda Dotson,Tom Egdorf,Michael S. Fisher,Rebecca de Frates,Emma Garren,Marissa Garwood,Amanda Gary,Nathalie Gaudreault,Keith B. Godfrey,Melissa Gorham,Hong Gu,Caroline Habel,Kristen Hadley,James Harrington,Julie A. Harris,Alex M. Henry,DiJon Hill,Samuel R Josephsen,Sara Kebede,Lisa Kim,Matthew Kroll,Brian Lee,Tracy Lemon,Katherine E. Link,Xiaoxiao Liu,Brian Long,Rusty Mann,Medea McGraw,Stefan Mihalas,Alice Mukora,Gabe J. Murphy,Lindsay Ng,Kiet Ngo,Thuc Nghi Nguyen,Philip R. Nicovich,Aaron Oldre,Daniel Park,Sheana Parry,Jed Perkins,Lydia Potekhina,David Reid,Miranda Robertson,David Sandman,Martin Schroedter,Cliff Slaughterbeck,Gilberto J. Soler-Llavina,Josef Sulc,Aaron Szafer,Bosiljka Tasic,Naz Taskin,Corinne Teeter,Nivretta Thatra,Herman Tung,Wayne Wakeman,Grace Williams,Rob Young,Zhi Zhou,Colin Farrell,Hanchuan Peng,Michael Hawrylycz,Ed Lein,Lydia Ng,Anton Arkhipov,Amy Bernard,John W. Phillips,Hongkui Zeng,Christof Koch +94 more
TL;DR: A single-cell characterization pipeline is established using standardized patch-clamp recordings in brain slices and biocytin-based neuronal reconstructions to establish a morpho-electrical taxonomy of cell types for the mouse visual cortex via unsupervised clustering analysis of multiple quantitative features.