V
Vladimir Holan
Researcher at Charles University in Prague
Publications - 101
Citations - 2322
Vladimir Holan is an academic researcher from Charles University in Prague. The author has contributed to research in topics: Mesenchymal stem cell & Stem cell. The author has an hindex of 26, co-authored 94 publications receiving 1978 citations. Previous affiliations of Vladimir Holan include Academy of Sciences of the Czech Republic.
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Journal ArticleDOI
A Comparative Study of the Therapeutic Potential of Mesenchymal Stem Cells and Limbal Epithelial Stem Cells for Ocular Surface Reconstruction
Vladimir Holan,Vladimir Holan,Peter Trosan,Peter Trosan,Cestmir Cejka,Cestmir Cejka,Eliska Javorkova,Eliska Javorkova,Alena Zajicova,Barbora Hermankova,Barbora Hermankova,Milada Chudíčková,Milada Chudíčková,Jitka Cejkova +13 more
TL;DR: Results show that BM‐MSCs' therapeutic effect on healing of injured corneal surface is comparable to that of tissue‐specific LSCs, and suggest that BM-MSCs can be used for ocular surface regeneration in cases when autologous L SCs are absent or difficult to obtain.
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The Role of Mouse Mesenchymal Stem Cells in Differentiation of Naive T-Cells into Anti-Inflammatory Regulatory T-Cell or Proinflammatory Helper T-Cell 17 Population
Eliska Svobodova,Magdalena Krulova,Alena Zajicova,Katerina Pokorna,Jana Prochazkova,Peter Trosan,Vladimir Holan +6 more
TL;DR: The results showed that MSCs represent important players that reciprocally regulate the development and differentiation of uncommitted naive T-cells into anti-inflammatory Foxp3(+) Tregs or proinflammatory RORγt(+) Th17 cell population and thereby can modulate autoimmune, immunopathological, and transplantation reactions.
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Prolonged desipramine treatment increases the production of interleukin-10, an anti-inflammatory cytokine, in C57BL/6 mice subjected to the chronic mild stress model of depression.
TL;DR: Prolonged desipramine treatment of stressed and non-stressed C57BL/6 mice induces an increase in the production of IL-10, an anti-inflammatory cytokine.
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A new animal model of (chronic) depression induced by repeated and intermittent lipopolysaccharide administration for 4 months
Marta Kubera,Katarzyna Curzytek,Weronika Duda,M. Leskiewicz,Agnieszka Basta-Kaim,Bogusława Budziszewska,Bogusława Budziszewska,Adam Roman,Alena Zajicova,Vladimir Holan,Ewa Szczęsny,Władysław Lasoń,Władysław Lasoń,Michael Maes,Michael Maes +14 more
TL;DR: The results suggest that repeated intermittent LPS injections to female mice may be a useful model of chronic depression and in particular for the depressogenic effects of long standing activation of the toll-like receptor IV complex.
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Treatment of ocular surface injuries by limbal and mesenchymal stem cells growing on nanofiber scaffolds.
Alena Zajicova,Katerina Pokorna,Katerina Pokorna,A Lencova,Magdalena Krulova,Magdalena Krulova,Eliska Svobodova,Eliska Svobodova,Šárka Kubinová,Eva Syková,Martin Pradny,Jiri Michalek,Jana Svobodova,Marcela Munzarova,Vladimir Holan,Vladimir Holan +15 more
TL;DR: The results thus show that nanofibers prepared from copolymer PA6/12 represent a convenient scaffold for growth of LSCs and M SCs and transfer to treat SC deficiencies and various ocular surface injuries.