V
Vladimir Yeremeev
Researcher at Max Planck Society
Publications - 20
Citations - 1853
Vladimir Yeremeev is an academic researcher from Max Planck Society. The author has contributed to research in topics: Immune system & Antigen. The author has an hindex of 18, co-authored 19 publications receiving 1749 citations. Previous affiliations of Vladimir Yeremeev include Centre national de la recherche scientifique & Imperial College London.
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Journal ArticleDOI
Fatal Mycobacterium tuberculosis infection despite adaptive immune response in the absence of MyD88.
Cecile Fremond,Vladimir Yeremeev,Delphine M. Nicolle,Muazzam Jacobs,Valérie F. J. Quesniaux,Bernhard Ryffel +5 more
TL;DR: It is demonstrated that MyD88 signaling is dispensable to raise an acquired immune response to MTB, but this acquired response is not sufficient to compensate for the profound innate immune defect and the inability of MyD 88 - / - mice to control MTB infection.
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Toll-like receptor pathways in the immune responses to mycobacteria.
Valérie F. J. Quesniaux,Cecile Fremond,Muazzam Jacobs,Shreemanta K. Parida,Delphine Nicolle,Vladimir Yeremeev,Franck Bihl,François Erard,Tania Botha,Michael Drennan,Marie-Noëlle Soler,Marc Le Bert,Bruno Schnyder,Bernhard Ryffel +13 more
TL;DR: Evidence from in vitro and in vivo investigations demonstrates TLR-dependent activation of innate immune response, while the induction of adaptive immunity to mycobacteria may be TLR independent.
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The adaptor molecule CARD9 is essential for tuberculosis control
Anca Dorhoi,Christiane Desel,Vladimir Yeremeev,Lydia Pradl,Volker Brinkmann,Hans-Joachim Mollenkopf,Karin Hanke,Olaf Gross,Jürgen Ruland,Stefan H. E. Kaufmann +9 more
TL;DR: Evidence that deregulated innate responses trigger excessive lung inflammation is provided and a pivotal role of CARD9 signaling is demonstrated in autonomous innate host defense against tuberculosis is demonstrated.
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Type I IFN signaling triggers immunopathology in tuberculosis‐susceptible mice by modulating lung phagocyte dynamics
Anca Dorhoi,Vladimir Yeremeev,Geraldine Nouailles,January Weiner,Sabine Jörg,Ellen Heinemann,Dagmar Oberbeck-Müller,Julia K. Knaul,Alexis Vogelzang,Stephen T. Reece,Karin Hahnke,Hans-Joachim Mollenkopf,Volker Brinkmann,Stefan H. E. Kaufmann +13 more
TL;DR: It is concluded that IFN I alters early innate events at the site of Mtb invasion leading to fatal immunopathology, furnish a mechanistic explanation for the detrimental role of IFn I in pulmonary TB and form a basis for understanding the complex roles ofIFN I in chronic inflammation.
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Induction of a type 1 immune response to a recombinant antigen from Mycobacterium tuberculosis expressed in Mycobacterium vaccae.
C. Abou-Zeid,Marie Pierre Gares,Jacqueline Inwald,Riny Janssen,Ying Zhang,Douglas B. Young,Charlotte Hetzel,Jonathan R. Lamb,Susan L. Baldwin,Ian M. Orme,Vladimir Yeremeev,Boris Nikonenko,Alexander S. Apt +12 more
TL;DR: The unexpected reduction in protective efficacy of M. vaccae expressing the 19-kDa antigen highlights the complexity of testing recombinant subunit vaccines and the need for a better understanding of the immune mechanisms required for effective vaccination against tuberculosis.