L
Lydia Pradl
Researcher at Max Planck Society
Publications - 7
Citations - 1006
Lydia Pradl is an academic researcher from Max Planck Society. The author has contributed to research in topics: Mycobacterium tuberculosis & Tuberculosis. The author has an hindex of 7, co-authored 7 publications receiving 909 citations.
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Journal ArticleDOI
Human tuberculous granulomas induce peripheral lymphoid follicle-like structures to orchestrate local host defence in the lung.
Timo Ulrichs,George A. Kosmiadi,Vsevolod Trusov,Sabine Jörg,Lydia Pradl,Marina Titukhina,Vladimir Mishenko,Nadya Gushina,Stefan H. E. Kaufmann +8 more
TL;DR: It is concluded that the follicular structures in the peripheral rim of granulomas serve as a morphological substrate for the orchestration of the enduring host response in pulmonary tuberculosis.
Journal ArticleDOI
The adaptor molecule CARD9 is essential for tuberculosis control
Anca Dorhoi,Christiane Desel,Vladimir Yeremeev,Lydia Pradl,Volker Brinkmann,Hans-Joachim Mollenkopf,Karin Hanke,Olaf Gross,Jürgen Ruland,Stefan H. E. Kaufmann +9 more
TL;DR: Evidence that deregulated innate responses trigger excessive lung inflammation is provided and a pivotal role of CARD9 signaling is demonstrated in autonomous innate host defense against tuberculosis is demonstrated.
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Cell-Wall Alterations as an Attribute of Mycobacterium tuberculosis in Latent Infection
Peter Seiler,Timo Ulrichs,Silke Bandermann,Lydia Pradl,Sabine Jörg,Veit Krenn,Lars Morawietz,Stefan H. E. Kaufmann,Peter Aichele +8 more
TL;DR: Evidence is presented that ZN-negative specimens represent Mycobacterium tuberculosis bacilli in a dormant state with distinct cell-wall alterations, and that detection of mycobacteria by cell- wall composition-independent staining using a polyclonal anti-M.
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Activation of the NLRP3 inflammasome by Mycobacterium tuberculosis is uncoupled from susceptibility to active tuberculosis.
Anca Dorhoi,Geraldine Nouailles,Sabine Jörg,Kristine Hagens,Ellen Heinemann,Lydia Pradl,Dagmar Oberbeck-Müller,María A. Duque-Correa,Stephen T. Reece,Jürgen Ruland,Roland Brosch,Jürg Tschopp,Olaf Gross,Stefan H. E. Kaufmann +13 more
TL;DR: During TB, Mycobacterium tuberculosis promotes NLRP3‐ and caspase‐1‐independent IL‐1β release in myeloid cells recruited to lung parenchyma and thus overcomesNLRP3 deficiency in vivo in experimental models.
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Differential Organization of the Local Immune Response in Patients with Active Cavitary Tuberculosis or with Nonprogressive Tuberculoma
Timo Ulrichs,George A. Kosmiadi,Sabine Jörg,Lydia Pradl,Marina Titukhina,Vladimir Mishenko,Nadya Gushina,Stefan H. E. Kaufmann +7 more
TL;DR: It is concluded that differential regulation of the local immune response is crucial for the containment of M. tuberculosis and that a continuous antigen-specific cross talk between the host immune system and M.culosis is ensured during latency.