V
Vladislava O. Melnikova
Researcher at University of Texas MD Anderson Cancer Center
Publications - 50
Citations - 2238
Vladislava O. Melnikova is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Melanoma & Metastasis. The author has an hindex of 27, co-authored 49 publications receiving 2101 citations.
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Cellular and molecular events leading to the development of skin cancer
TL;DR: Resistance to cell death is a key event in photocarcinogenesis and conversely, elimination of cells containing excessive UV-induced DNA damage is aKey step in protecting against skin cancer development.
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Targeting melanoma growth and metastasis with systemic delivery of liposome-incorporated protease-activated receptor-1 small interfering RNA
Gabriel J. Villares,Maya Zigler,Hua Wang,Vladislava O. Melnikova,Hong Wu,Ran Friedman,Michael C. Leslie,Pablo E. Vivas-Mejia,Gabriel Lopez-Berestein,Anil K. Sood,Menashe Bar-Eli +10 more
TL;DR: It is proposed that siRNA incorporated into DOPC nanoparticles could be delivered systemically and used as a new modality for melanoma treatment and stably silence PAR-1 through the use of lentiviral short hairpin RNA.
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Expression profiling of Galectin-3-depleted melanoma cells reveals its major role in melanoma cell plasticity and vasculogenic mimicry.
TL;DR: It is shown that silencing of Gal-3 expression with small hairpin RNA results in a loss of tumorigenic and metastatic potential of melanoma cells and plays an essential role during the acquisition of vasculogenic mimicry and angiogenic properties associated with melanoma progression.
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Platelet-activating factor mediates MMP-2 expression and activation via phosphorylation of cAMP-response element-binding protein and contributes to melanoma metastasis.
TL;DR: PAF acts as a promoter of melanoma metastasis in vivo and it is proposed that metastatic melanoma cells overexpressing CREB/ATF-1 are better equipped than nonmetastatic cells to respond to PAF within the tumor microenvironment.
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Genomic alterations in spontaneous and carcinogen-induced murine melanoma cell lines.
TL;DR: Results indicate that genetic alterations in p16Ink4a/p19Arf, p53 and ras-MAPK pathways can cooperate in the development of murine melanoma.