Vojo Deretic

TL;DR: The existence of an intermediate, whose production is inhibited by isonicotinic acid hydrazide, which plays a negative feedback regulatory role in the metabolism of mycolic acids are revealed by the overexpression of the antigen 85 complex is postulated.

TL;DR: The mechanisms of secretion/passive release of the potent pro-inflammatory cytokine IL-1β are focused on, as a prototypical leaderless cytosolic protein cargo studied in the context of secretory autophagy.

TL;DR: Results suggest a link between physiological processes dependent on heme and conditions conducive to algD expression and mucoidy and suggest the presence of two newly identified P. aeruginosa genes with predicted gene products homologous to known porphobilinogen deaminases from other organisms, and uroporphyrinogen III cosynthase from Escherichia coli.

TL;DR: IRGM and its interactors mAtg8s close a loop between the autophagosomal pathway and the control of lysosomal biogenesis by TFEB, thus ensuring coordinated activation of the two systems that eventually merge during autophagy.

TL;DR: The results suggest that the lasB gene and the alginate system are co‐ordinately regulated at a level parallel to or above the algR gene.