Vojo Deretic

TL;DR: Control of the algD gene coding for GDPmannose dehydrogenase, which has previously been shown to undergo antibiotic promoted chromosomal amplification resulting in the emergence of the mucoid phenotype, provides a basis for better understanding the control of mucoidy in P. aeruginosa.

TL;DR: It is shown that Rab22a defines the critical checkpoint for Rab7 conversion on phagosomes, allowing or disallowing organellar transition into a late endosomal compartment and preventing Rab7 acquisition and blocking phagolysosomal biogenesis.

TL;DR: During chronic infections in cystic fibrosis, persistence of Pseudomonas aeruginosa is associated with conversion into forms that are characterized by a mucoid colony morphology, rough lipopolysaccharide and, paradoxically, decreased systemic virulence.

TL;DR: The results suggest that algU itself is subject to complex regulation and is inducible by extreme heat shock, that the alginate system is a subset of the stress-responsive elements controlled by AlgU, and that Alg U and, by extension, its homologs in other organisms may play a role in bacterial virulence and adjustments to adverse growth conditions.

TL;DR: Further pools of PI3P, upstream of mTOR and on the endocytic pathway, may modulate autophagy indirectly, suggesting that otherPI3P phosphatases might be involved in this process.