V
Volodymyr Gerzanich
Researcher at University of Maryland, Baltimore
Publications - 115
Citations - 9204
Volodymyr Gerzanich is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Cerebral edema & Sulfonylurea receptor. The author has an hindex of 48, co-authored 109 publications receiving 8224 citations. Previous affiliations of Volodymyr Gerzanich include Vollum Institute & University of Pennsylvania.
Papers
More filters
Journal ArticleDOI
Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications
TL;DR: A new theory is suggested suggesting that ischaemia-induced capillary dysfunction can be attributed to de novo synthesis of a specific ensemble of proteins that determine osmotic and hydraulic conductivity in Starling's equation, and whose expression is driven by a distinct transcriptional program.
Journal ArticleDOI
Newly expressed SUR1-regulated NC(Ca-ATP) channel mediates cerebral edema after ischemic stroke.
J. Marc Simard,Mingkui Chen,Kirill V Tarasov,Sergei Bhatta,Svetlana Ivanova,Ludmila Melnitchenko,Natalya Tsymbalyuk,G. Alexander West,Volodymyr Gerzanich +8 more
TL;DR: It is indicated that the NCCa-ATP channel is crucially involved in development of cerebral edema, and that targeting SUR1 may provide a new therapeutic approach to stroke.
Journal ArticleDOI
Molecular pathophysiology of cerebral edema
TL;DR: Past models and current knowledge regarding the molecular and cellular pathophysiology of cerebral edema are discussed.
Journal Article
Nicotine-induced increase in neuronal nicotinic receptors results from a decrease in the rate of receptor turnover.
TL;DR: In this paper, it was shown that nicotine-induced up-regulation reflects properties of the alpha 4 β 2 receptor protein, rather than being an adaptive response unique to the neurons in which these receptors are normally expressed.
Journal ArticleDOI
Assembly of Human Neuronal Nicotinic Receptor α5 Subunits with α3, β2, and β4 Subunits
Fan Wang,Volodymyr Gerzanich,Gregg B. Wells,René Anand,Xiao Peng,Kent T. Keyser,Jon Lindstrom +6 more
TL;DR: Nicotinic acetylcholine receptors formed from combinations of α3, β2, β4, and α5 subunits are found in chicken ciliary ganglion neurons and some human neuroblastoma cell lines and Nicotine, like the structurally similar toxin epibatidine, distinguishes by binding affinity two subtypes of receptors containing α3 subunits in SH-SY5Y cells.