W
W. C. Van Voorhis
Researcher at University of Washington
Publications - 27
Citations - 2697
W. C. Van Voorhis is an academic researcher from University of Washington. The author has contributed to research in topics: Antigen & Monocyte. The author has an hindex of 19, co-authored 27 publications receiving 2636 citations.
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Journal ArticleDOI
Identification of the C3bi receptor of human monocytes and macrophages by using monoclonal antibodies.
Samuel D. Wright,P E Rao,W. C. Van Voorhis,Lydia S. Craigmyle,K Iida,M A Talle,E F Westberg,Gideon Goldstein,Samuel C. Silverstein +8 more
TL;DR: The C3bi receptor of human M phi is a complex composed of two polypeptides, Mr 185,000 and 105,000, and monoclonal antibodies reacting with four distinct antigenic determinants of this complex are identified.
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Human dendritic cells. Enrichment and characterization from peripheral blood.
TL;DR: It is concluded that dendritic cells circulate in man, and represent the principal cell type required for the initiation of several immune responses.
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Relative efficacy of human monocytes and dendritic cells as accessory cells for T cell replication.
TL;DR: The dendritic cell is the major stimulator of T cell replication in man, and class II products are necessary but not sufficient for the stimulation of Tcell proliferation in man.
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Specific antimononuclear phagocyte monoclonal antibodies. Application to the purification of dendritic cells and the tissue localization of macrophages.
W. C. Van Voorhis,Ralph M. Steinman,L S Hair,Jeremy Luban,Margit D. Witmer,S Koide,Zanvil A. Cohn +6 more
TL;DR: The 3C10 monoclonal provides a clear distinction between human mononuclear phagocytes and dendritic cells, and immunocytochemical staining of tissue sections reveals that3C10+ macrophages are anatomically segregated from dendrite cells.
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Dendritic cells are critical accessory cells for thymus-dependent antibody responses in mouse and in man
TL;DR: It is reported that dendritic cells are necessary and potent accessory cells for anti-sheep erythrocyte responses in both mouse and man and that DC are required for the development of T-dependent antibody responses by mouse and human lymphocytes in vitro.