Samuel C. Silverstein

TL;DR: It is shown that cultured adult mouse astrocytes migrate in response to monocyte chemoattractant protein-1 (MCP-1), a chemokine present in AD lesions, and cease migration upon interaction with immobilized Aβ1–42, which suggests a novel mechanism for the accumulation of Astrocytes around Aβ deposits.

TL;DR: It is reported that class A scavenger receptors mediate adhesion of rodent microglia and human monocytes to β-amyloid fibril-coated surfaces leading to secretion of reactive oxygen species and cell immobilization.

TL;DR: Findings indicate that L. pneumophila falls into a select category of bacterial pathogens that evade host defenses by parasitizing monocytes, and it remains to be determined whether cell-mediated immunity plays a dominant role in host defense against L.neumophila as it does against other intracellular pathogens.

TL;DR: The C3bi receptor of human M phi is a complex composed of two polypeptides, Mr 185,000 and 105,000, and monoclonal antibodies reacting with four distinct antigenic determinants of this complex are identified.

TL;DR: Results indicate that attachment of a particle to specific receptors on the macrophage plasma membrane is not sufficient to trigger ingestion of that particle, and that ingestion requires the sequential, circumferential interaction of particle-bound ligands with specific plasma membrane receptors not involved in the initial attachment process.