W. Dean Harman

TL;DR: It is proposed that NTZ− intercepts PFOR at an early step in the formation of the lactyl-TPP transition intermediate, resulting in the reversal of pyruvate binding prior to decarboxylation and in coordination with proton transfer to NTZ.

TL;DR: Examination of the ability of M1 and M2 to undergo in vitro bioactivation by electrochemical and enzymatic methods and experiments with chemical P450 inhibitors and cDNA-expressed P450 enzymes reveal that this oxidation is catalyzed by several P450s, and that P450 2E1 and 1A2 play the primary role in the formation of C1 while P4501A2 is most important for the production of C2.

TL;DR: It is shown that muscarinic analgesia is exclusively mediated by a combination of M(2) and M(4) mAChRs at both spinal and supraspinal sites, and this finding should be of considerable relevance for the development of receptor subtype-selectiveMuscarinic agonists as novel analgesic drugs.

TL;DR: A comparison of electron-donating abilities of the hydridotris(pyrazolyl)borate ligand and cyclopentadienyl ligand toward transition metals is presented in this article.

TL;DR: A new generation of dearomatizing π-bases having the general form {TpM(L)(π-acid)}, which show reactivity patterns similar to those of their pentaammineosmium(II) predecessor, binding aromatic molecules across two carbons and subsequently activating these ligands toward electrophilic addition and cycloaddition reactions.