G
Gary Sisson
Researcher at Dalhousie University
Publications - 21
Citations - 2159
Gary Sisson is an academic researcher from Dalhousie University. The author has contributed to research in topics: Gene & Virus. The author has an hindex of 18, co-authored 20 publications receiving 2017 citations. Previous affiliations of Gary Sisson include Halifax.
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Journal ArticleDOI
Tumor Cell Marker PVRL4 (Nectin 4) Is an Epithelial Cell Receptor for Measles Virus
Ryan S. Noyce,Daniel G. Bondre,Daniel G. Bondre,Michael N. Ha,Michael N. Ha,Liang Tzung Lin,Liang Tzung Lin,Gary Sisson,Gary Sisson,Ming-Sound Tsao,Ming-Sound Tsao,Christopher D. Richardson,Christopher D. Richardson +12 more
TL;DR: It is demonstrated that wild type measles virus infects primary airway epithelial cells grown in fetal calf serum and many adenocarcinoma cell lines of the lung, breast, and colon and several strains of measles virus were shown to use PVRL4 as a receptor.
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Metronidazole resistance in Helicobacter pylori is due to null mutations in a gene (rdxA) that encodes an oxygen‐insensitive NADPH nitroreductase
Avery Goodwin,Dangeruta Kersulyte,Gary Sisson,Veldhuyzen van Zanten Sj,Douglas E. Berg,Paul S. Hoffman +5 more
TL;DR: It is shown that MtzR results from loss of oxygen‐insensitive NADPH nitroreductase activity, and suggests that many rdxA (MtzR) mutations may have been selected by prior use of Mtz against other infections.
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Antiparasitic drug nitazoxanide inhibits the pyruvate oxidoreductases of Helicobacter pylori, selected anaerobic bacteria and parasites, and Campylobacter jejuni
Paul S. Hoffman,Gary Sisson,Matthew A. Croxen,Kevin D. Welch,W. Dean Harman,Nunilo Cremades,Michael G. Morash +6 more
TL;DR: It is proposed that NTZ− intercepts PFOR at an early step in the formation of the lactyl-TPP transition intermediate, resulting in the reversal of pyruvate binding prior to decarboxylation and in coordination with proton transfer to NTZ.
Journal ArticleDOI
The Helicobacter pylori chemotaxis receptor TlpB (HP0103) is required for pH taxis and for colonization of the gastric mucosa.
TL;DR: P pH taxis, like motility and urease activity, is essential for colonization and persistence in the gastric mucosa, and thus TlpB function might represent a novel target in the development of therapeutics that blind tactic behavior.
Journal ArticleDOI
Enzymes Associated with Reductive Activation and Action of Nitazoxanide, Nitrofurans, and Metronidazole in Helicobacter pylori
Gary Sisson,Avery Goodwin,Ausra Raudonikiene,Nicky J. Hughes,Asish K. Mukhopadhyay,Douglas E. Berg,Paul S. Hoffman,Paul S. Hoffman +7 more
TL;DR: It is concluded that POR, an essential enzyme, is responsible for most or all of the bactericidal effects of NTZ against H. pylori.