Paul S. Hoffman

TL;DR: It is shown that MtzR results from loss of oxygen‐insensitive NADPH nitroreductase activity, and suggests that many rdxA (MtzR) mutations may have been selected by prior use of Mtz against other infections.

TL;DR: A role for surface-exposed Hsp60 in invasion of HeLa cells by L. pneumophila is established as well as a monospecific anti-OmpS serum that inhibited the association of both virulent and avirulent strains of L.neumophila to He La cells, suggesting that while both HSp60 and OmpS may mediate bacterial association to HeLa Cells, only virulent strains selectively displayed Hsp 60 on their surfaces.

TL;DR: It is proposed that NTZ− intercepts PFOR at an early step in the formation of the lactyl-TPP transition intermediate, resulting in the reversal of pyruvate binding prior to decarboxylation and in coordination with proton transfer to NTZ.

TL;DR: Allelic replacement mutagenesis revealed ahpC to be essential, suggesting a critical role for AhpC in defending H. pylori against oxygen toxicity.

TL;DR: P pH taxis, like motility and urease activity, is essential for colonization and persistence in the gastric mucosa, and thus TlpB function might represent a novel target in the development of therapeutics that blind tactic behavior.