W
Waddah A. Alrefai
Researcher at Veterans Health Administration
Publications - 150
Citations - 4433
Waddah A. Alrefai is an academic researcher from Veterans Health Administration. The author has contributed to research in topics: Intestinal mucosa & SLC26A3. The author has an hindex of 32, co-authored 132 publications receiving 3665 citations. Previous affiliations of Waddah A. Alrefai include University of Illinois at Chicago.
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Journal ArticleDOI
Identification of the Niemann-Pick C1–like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor
Bruno Sainz,Naina Barretto,Danyelle N. Martin,Nobuhiko Hiraga,Michio Imamura,Snawar Hussain,Katherine A. Marsh,Xuemei Yu,Kazuaki Chayama,Waddah A. Alrefai,Susan L. Uprichard +10 more
TL;DR: It is shown that the cellular Niemann-Pick C1–like 1 (NPC1L1) cholesterol uptake receptor is an HCV entry factor amendable to therapeutic intervention and discovered a new antiviral target and potential therapeutic agent.
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Bile Acid Transporters: Structure, Function, Regulation and Pathophysiological Implications
TL;DR: Current knowledge about structure, function and molecular characterization of bile acid transporters are highlighted and the implications of their defects in various hepatic and intestinal disorders are discussed.
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Phospholipid Remodeling and Cholesterol Availability Regulate Intestinal Stemness and Tumorigenesis
Bo Wang,Xin Rong,Elisa N.D. Palladino,Jiafang Wang,Alan M. Fogelman,Martin G. Martin,Waddah A. Alrefai,Waddah A. Alrefai,David A. Ford,Peter Tontonoz +9 more
TL;DR: An unexpected link between membrane phospholipid remodeling and cholesterol biosynthesis is revealed and it is demonstrated that cholesterol itself acts as a mitogen for ISCs and drives ISC proliferation and tumorigenesis.
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Expression and membrane localization of MCT isoforms along the length of the human intestine
Ravinder K. Gill,Seema Saksena,Waddah A. Alrefai,Zaheer Sarwar,Jay L. Goldstein,Robert J. Carroll,Krishnamurthy Ramaswamy,Pradeep K. Dudeja +7 more
TL;DR: It is speculated that distinct MCT isoforms may be involved in SCFA transport across the apical or basolateral membranes in polarized colonic epithelial cells.
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Regulation of monocarboxylate transporter 1 (MCT1) promoter by butyrate in human intestinal epithelial cells: Involvement of NF‐κB pathway
Alip Borthakur,Seema Saksena,Ravinder K. Gill,Waddah A. Alrefai,Krishnamurthy Ramaswamy,Pradeep K. Dudeja +5 more
TL;DR: It is demonstrated that butyrate, a substrate for MCT1, stimulates M CT1 promoter activity in Caco‐2 cells and the involvement of NF‐κB pathway in the regulation of MCT 1 promoter activity bybutyrate is demonstrated.