Bo Wang

TL;DR: It is demonstrated that deletion of mouse Mir122 resulted in hepatosteatosis, hepatitis, and the development of tumors resembling HCC, demonstrating critical functions for miR-122 in the maintenance of liver homeostasis and have important therapeutic implications, including the potential utility of mi R-122 delivery for selected patients with HCC and the need for careful monitoring of patients receiving miR -122 inhibition therapy for HCV.

TL;DR: It is suggested that the loss of multifunctional miR-122 contributes to the malignant phenotype of HCC cells, and mi R-122 mimetic alone or in combination with anticancer drugs can be a promising therapeutic regimen against liver cancer.

TL;DR: Up-regulation of several miR-1 targets including FoxP1, MET, and HDAC4 in primary human HCCs and down- regulation of their expression in 5-AzaC-treated HCC cells suggest their role in hepatocarcinogenesis.

TL;DR: It is reported that micro-RNA-1 (miR-1), abundant in the cardiac and smooth muscles, is expressed in the lung and is down-regulated in human primary lung cancer tissues and cell lines and has potential therapeutic application against lung cancers.

TL;DR: Upregulation of miR-181b at early stages of feeding CDAA diet promotes hepatocarcinogenesis and enhanced resistance of HCC cells to the anticancer drug doxorubicin.