Showing papers by "Wafaa S. Hamama published in 2017"
TL;DR: In this paper, the reaction of 5-amino-3-methylisoxazole with formalin and secondary amines gave the corresponding Mannich bases and the newly synthesized compounds were screened for their antitumor activity compared with 5fluorouracil as a well-known cytotoxic agent using Ehrlich ascites carcinoma cells.
16 citations
TL;DR: A review of the chemical properties associated with sildenafil and its analogues can be found in this article, where the authors focus on chemical properties of sildeneafil.
9 citations
TL;DR: In this paper, the synthesis of β-Unsaturated carbonyl compounds using the Knoevenagel condensation between 2-substituted quionoline-3-carboxaldehyde 1a and/or 1b with active methylene compounds.
9 citations
TL;DR: In this article, the authors showed that most of the compounds anchored to phenothiazine moiety displayed good antioxidant activity using ABTS method and exhibited high protection against DNA damage induced by the bleomycin iron complex.
8 citations
TL;DR: In this article, a review aimed to document the publications concerning the synthesis and chemical reactivity and reactions of lawsone reported by research groups, which is a natural product which shows significant biological activity.
8 citations
TL;DR: In this article, the synthesis and heterocyclization reactions of aminocoumarines were investigated. And it was found that the cyclocondensation process depended mainly on the chemoselective and regioselectivity states of the enamino skeleton.
Abstract: Coumarin and their derivatives are important groups of heterocyclic compounds. They have attracted considerable interest because of their great biological importance. This review describes the work on the synthesis and heterocyclization reactions of aminocoumarines. It was found that the cyclocondensation process depended mainly on the chemoselective and regioselectivity states of the enamino skeleton.
8 citations
TL;DR: In this paper, 2-methyl-2-phenyl-1,3-oxathiolan-5-one (1) was used to give unpredicative opened and fused heterocyclic systems.
7 citations
7 citations
TL;DR: In this article, a tricyclic heterocyclic system was synthesized by reaction of 1 with chloroacetonitrile, 4-oxo-4-phenylbutanoic acid and/or diethylmalonate in presence of acetyl chloride.
7 citations
TL;DR: In this paper, the authors exploited the utilization of 2-methyl-2-phenyl-1,3-oxathiolan-5-one that acts as activated thioglycolic acid as mercaptoacetyl transfer agent to build new pyridinonethiol derivatives via multicomponent domino reactions of 1 with different acyclic or cyclic α,β-unsaturated carbonyl compounds and aniline using CeCl3∙7H2O/KI as Lewis acid catalyst.
6 citations
TL;DR: A new class of spiro compounds as dispiro[indoline-3,2′-pyrrolidine-3′,3″-quinoline] and spiro[imidazole-4,3′-quin Caroline have been developed from quinolone derivative adopting modern synthetic methodologies.
TL;DR: A survey of the advances in the methods of formation and chemical reactivity of bicyclic [1, 3, 4]thiadiazole 5-5 systems containing ring-junction nitrogen over the period from 1989 to the beginning of 2017 is given in this article.
Abstract: This review provides a survey of the advances in the methods of formation and chemical reactivity of bicyclic [1,3,4]thiadiazole 5-5 systems containing ring-junction nitrogen over the period from 1989 to the beginning of 2017
TL;DR: A series of nitrogenous compounds containing 1,4-naphhoquinone moiety such as lawsone, benzo[g]quinolone-5,10-diones, benzosquioxioxioxine-6,11-dionses analogs was synthesized by reaction of Lawsone (1) with different reagents as mentioned in this paper.
TL;DR: In this article, arylidene derivative was synthesized by the transformation of chloroacetamide derivative 2 with NH4SCN and the condensation of 3 with p-anisaldehyde afforded the corresponding arylsidene derivatives 4.
Abstract: Thiazolidin-4-one derivative 3 was synthesized by the transformation of chloroacetamide derivative 2 with NH4SCN.The condensation of 3 with p-anisaldehyde afforded the corresponding arylidene derivative 4. Also, the alkylation of chloroacetamide derivative 2 with different heterocyclic compounds was investigated. Annulation of 5-amino-3-methylisoxazole (1) with α-halocarbonyl compounds 12 and 14 furnished pyrrolo[3,2-d]isoxazole and isoxazolo[5,4-b]azepin-6-one derivatives 13 and 15, respectively, while reaction of 1 with 1-chloro-4-(chloromethyl)benzene gave the monoalkylated product 17. The newly synthesized compounds were screened for their antitumor activity, and the geometry optimizations are in a good agreement with the experimentally observed data.
TL;DR: In this article, a review covers many reports of the applications of multicomponent domino reactions in the synthesis of novel stereocontrolled mercapto-heterocycles from the 1972 up to the end of 2016.
01 Jan 2017
TL;DR: In this paper, the newly synthesized compounds were screened for their antimicrobial activities and their geometrical optimization calculations through the Density Functional Theory (DFT) method for the new synthesised compounds were in a good agreement with the proposed structures.
Abstract: Schiff's bases 2-5 were synthesized by reaction of 5-phenyl-5H-thiazolo[4,3-b][1,3,4]thiadiazol-2-amine (1) with some aldehydes and ketone. Cycloaddition reaction of ketimine 5 with thioglycolic acid or thiosemicarbazide afforded spirothiazolidinone and spirotriazole derivatives 6, 7, respectively. Transformation of 1 with the appropriate α-halocarbonyl compounds produced thiazolo[4,3-b][1,3,4]thiadiazole derivatives 8 and 9. The newly synthesized compounds were screened for their antimicrobial activities. Furthermore, their geometrical optimization calculations through the Density Functional Theory (DFT) method for the new synthesized compounds were in a good agreement with the proposed structures.