W
Wai-Hong Tham
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 92
Citations - 4765
Wai-Hong Tham is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Plasmodium falciparum & Plasmodium vivax. The author has an hindex of 33, co-authored 78 publications receiving 3745 citations. Previous affiliations of Wai-Hong Tham include Massachusetts Institute of Technology & Royal Melbourne Hospital.
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Journal ArticleDOI
Humoral and circulating follicular helper T cell responses in recovered patients with COVID-19.
Jennifer A Juno,Hyon-Xhi Tan,Wen Shi Lee,Arnold Reynaldi,Hannah G. Kelly,Hannah G. Kelly,Kathleen M. Wragg,Robyn Esterbauer,Robyn Esterbauer,Helen E Kent,Helen E Kent,C. Jane Batten,Francesca L Mordant,Nicholas A Gherardin,Nicholas A Gherardin,Phillip Pymm,Phillip Pymm,Melanie H. Dietrich,Melanie H. Dietrich,Nichollas E. Scott,Wai-Hong Tham,Dale I. Godfrey,Dale I. Godfrey,Kanta Subbarao,Miles P. Davenport,Stephen J. Kent,Stephen J. Kent,Stephen J. Kent,Adam K. Wheatley,Adam K. Wheatley +29 more
TL;DR: It is found that S-specific antibodies, memory B cells and cTFH are consistently elicited after SARS-CoV-2 infection, demarking robust humoral immunity and positively associated with plasma neutralizing activity, suggesting that vaccines might require strategies to selectively target the most potent neutralizing epitopes.
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A Genome-Wide Screen Identifies Genes Required for Centromeric Cohesion
TL;DR: The screen described here provides a comprehensive analysis of the genes required for the meiotic cell cycle and identifies three factors important for the stepwise loss of sister chromatid cohesion.
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Structure-function analysis of the tobacco mosaic virus resistance gene N.
TL;DR: It is shown that amino acids conserved among the Toll/IL-1R/plant R gene TIR domain and NBS-containing proteins play a critical role in N-mediated TMV resistance, and many amino acid substitutions in the TIR, NBS, and LRR domains of N lead to a partial loss-of-function phenotype.
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Revealing the Sequence and Resulting Cellular Morphology of Receptor-Ligand Interactions during Plasmodium falciparum Invasion of Erythrocytes
Greta E. Weiss,Paul R. Gilson,Tana Taechalertpaisarn,Wai-Hong Tham,Nienke W.M. de Jong,Katherine L. Harvey,Freya J. I. Fowkes,Paul N. Barlow,Julian C. Rayner,Gavin J. Wright,Alan F. Cowman,Brendan S. Crabb +11 more
TL;DR: This work provides a rational basis to combine sequentially acting merozoite vaccine candidates in a single multi-receptor-blocking vaccine.
Journal ArticleDOI
Complement receptor 1 is the host erythrocyte receptor for Plasmodium falciparum PfRh4 invasion ligand
Wai-Hong Tham,Danny W. Wilson,Sash Lopaticki,Christoph Q. Schmidt,Patience B. Tetteh-Quarcoo,Patience B. Tetteh-Quarcoo,Paul N. Barlow,Dave Richard,Jason Corbin,James G. Beeson,James G. Beeson,Alan F. Cowman,Alan F. Cowman +12 more
TL;DR: It is demonstrated that CR1 is an erythrocyte receptor used by the parasite ligand PfRh4 for P. falciparum invasion, and that Parasite invasion via sialic acid–independent pathways is reduced in low-CR1 ERYthrocytes due to limited availability of this receptor on the surface.