W
Wal Tsing Chan
Researcher at Rockefeller University
Publications - 1
Citations - 1281
Wal Tsing Chan is an academic researcher from Rockefeller University. The author has contributed to research in topics: Glyoxylate cycle & Isocitrate lyase. The author has an hindex of 1, co-authored 1 publications receiving 1228 citations.
Papers
More filters
Journal ArticleDOI
Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase
John D. McKinney,John D. McKinney,John D. McKinney,Kerstin Höner zu Bentrup,Kerstin Höner zu Bentrup,Kerstin Höner zu Bentrup,Ernesto J. Muñoz-Elías,Andras Miczak,Andras Miczak,Bing Chen,Wal Tsing Chan,Dana L. Swenson,Dana L. Swenson,Dana L. Swenson,James C. Sacchettini,William R. Jacobs,David G. Russell,David G. Russell +17 more
TL;DR: It is reported that persistence of M. tuberculosis in mice is facilitated by isocitrate lyase (ICL), an enzyme essential for the metabolism of fatty acids, an observation with important implications for the treatment of chronic tuberculosis.