W
Waliul I. Khan
Researcher at McMaster University
Publications - 113
Citations - 7399
Waliul I. Khan is an academic researcher from McMaster University. The author has contributed to research in topics: Inflammation & Inflammatory bowel disease. The author has an hindex of 41, co-authored 98 publications receiving 5797 citations. Previous affiliations of Waliul I. Khan include Akita University & Hamilton Health Sciences.
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Journal ArticleDOI
Chronic Gastrointestinal Inflammation Induces Anxiety-Like Behavior and Alters Central Nervous System Biochemistry in Mice
Premysl Bercik,Elena F. Verdu,Jane A. Foster,Jane A. Foster,Joseph Macri,Murray A. Potter,Xiaxing Huang,Paul Malinowski,Wendy Jackson,Patricia Blennerhassett,Karen A Neufeld,Karen A Neufeld,Jun Lu,Waliul I. Khan,Irene Corthesy-Theulaz,Christine Cherbut,Gabriela Bergonzelli,Stephen M. Collins +17 more
TL;DR: Chronic gastrointestinal inflammation induces anxiety-like behavior and alters central nervous system biochemistry, which can be normalized by inflammation-dependent and -independent mechanisms, neither of which requires the integrity of the vagus nerve.
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Investigating Intestinal Inflammation in DSS-induced Model of IBD
TL;DR: The methods by which colitis development and the resulting inflammatory response can be characterized following administration of dextran sulphate sodium (DSS) are described, which can be used to evaluate the intestinal inflammatory response in animal models of experimental colitis.
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Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis
Justin D. Crane,Rengasamy Palanivel,Emilio P. Mottillo,Adam L. Bujak,Huaqing Wang,Rebecca J. Ford,Andrew Collins,Regje M. E. Blümer,Morgan D. Fullerton,Julian M. Yabut,Janice J. Kim,Jean-Eric Ghia,Shereen M. Hamza,Katherine M. Morrison,Jonathan D. Schertzer,Jason R.B. Dyck,Waliul I. Khan,Gregory R. Steinberg +17 more
TL;DR: It is found that Tph1-deficient mice fed a high-fat diet (HFD) are protected from obesity, insulin resistance and nonalcoholic fatty liver disease (NAFLD) while exhibiting greater energy expenditure by BAT.
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Serotonin Has a Key Role in Pathogenesis of Experimental Colitis
Jean-Eric Ghia,Nan Li,Huaqing Wang,Matthew Collins,Yikang Deng,Rami T. El–Sharkawy,Francine Côté,J. Mallet,Waliul I. Khan +8 more
TL;DR: 5-HT is involved in the pathogenesis of inflammation in experimental colitis, indicating a critical role for nuclear factor kappaB signaling in 5-HT-mediated activation of immune cells.
Journal ArticleDOI
Intestinal Nematode Infection Ameliorates Experimental Colitis in Mice
Waliul I. Khan,Patricia Blennerhasset,Ashwin K. Varghese,S. K. Chowdhury,P. Omsted,Yikang Deng,Stephen M. Collins +6 more
TL;DR: Prior nematode infection reduced the severity of colitis both macroscopically and histologically together with a decreased mortality and was correlated with a down-regulation of MPO activity, Th1-type cytokine expression in colonic tissue, and emergence of a Th2-type immune response.