Jonathan D. Schertzer

TL;DR: It is found that, when maintained under germ-free conditions, mice do not display an age-related increase in circulating pro-inflammatory cytokine levels, suggesting that aging-associated microbiota promote inflammation and that reversing these age- related microbiota changes represents a potential strategy for reducing age-associated inflammation and the accompanying morbidity.

TL;DR: It is established that inhibitory phosphorylation of Acc by Ampk is essential for the control of lipid metabolism and, in the setting of obesity, for metformin-induced improvements in insulin action.

TL;DR: The results suggest that AMPK activation could explain some beneficial effects of salsalate and aspirin in humans, and a possible molecular mechanism of action for a metabolite of aspirin is described.

TL;DR: It is found that Tph1-deficient mice fed a high-fat diet (HFD) are protected from obesity, insulin resistance and nonalcoholic fatty liver disease (NAFLD) while exhibiting greater energy expenditure by BAT.

TL;DR: It is reported that AMP-activated protein kinase (AMPK) regulates GLUT4 transcription through the histone deacetylase (HDAC)5 transcriptional repressor through the signal transduction pathway linking cellular energy charge to gene transcription directed at restoring cellular and whole-body energy balance.