F
Francine Côté
Researcher at French Institute of Health and Medical Research
Publications - 40
Citations - 2294
Francine Côté is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Serotonin & TPH1. The author has an hindex of 20, co-authored 37 publications receiving 1924 citations. Previous affiliations of Francine Côté include University of Paris & Paris Descartes University.
Papers
More filters
Journal ArticleDOI
Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function
Francine Côté,Etienne A. Thévenot,Cécile Fligny,Yves Fromes,Michèle Darmon,Marie-Anne Ripoche,Elisa Bayard,Naïma Hanoun,Françoise Saurini,Philippe Lechat,Luisa Dandolo,Michel Hamon,Jacques Mallet,Guilan Vodjdani +13 more
TL;DR: It is established that the neuronal tph2 is expressed in neurons of the raphe nuclei and of the myenteric plexus, whereas the nonneuronal tph1, as detected by β-galactosidase expression, is in the pineal gland and the enterochromaffin cells.
Journal ArticleDOI
Serotonin Has a Key Role in Pathogenesis of Experimental Colitis
Jean-Eric Ghia,Nan Li,Huaqing Wang,Matthew Collins,Yikang Deng,Rami T. El–Sharkawy,Francine Côté,J. Mallet,Waliul I. Khan +8 more
TL;DR: 5-HT is involved in the pathogenesis of inflammation in experimental colitis, indicating a critical role for nuclear factor kappaB signaling in 5-HT-mediated activation of immune cells.
Journal ArticleDOI
An activin receptor IIA ligand trap corrects ineffective erythropoiesis in β-thalassemia
Michael Dussiot,Thiago Trovati Maciel,Aurélie Fricot,Céline Chartier,Olivier Negre,Joel Veiga,Damien Grapton,Etienne Paubelle,Emmanuel Payen,Yves Beuzard,Philippe Leboulch,Jean-Antoine Ribeil,Jean-Benoît Arlet,Francine Côté,Geneviève Courtois,Yelena Ginzburg,Thomas O. Daniel,Rajesh Chopra,Victoria Sung,Olivier Hermine,Ivan C. Moura +20 more
TL;DR: Observations suggest that ActRIIA ligand traps may have therapeutic relevance in β-thalassemia by suppressing the deleterious effects of GDF11, a cytokine which blocks terminal erythroid maturation through an autocrine amplification loop involving oxidative stress and α-globin precipitation.
Journal ArticleDOI
Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration.
Nathalie Cloutier,Isabelle Allaeys,Geneviève Marcoux,Kellie R. Machlus,Benoit Mailhot,Anne Zufferey,Tania Lévesque,Yann Becker,Nicolas Tessandier,Imene Melki,Huiying Zhi,Guy G. Poirier,Matthew T. Rondina,Joseph E. Italiano,Louis Flamand,Steven E. McKenzie,Francine Côté,Bernhard Nieswandt,Waliul I. Khan,Matthew J. Flick,Peter J. Newman,Steve Lacroix,Paul R. Fortin,Eric Boilard +23 more
TL;DR: It is proposed that in response to circulating ICs, platelets are a crucial mediator of the inflammatory response highly relevant to sepsis, viremia, and anaphylaxis and may explain platelet count fluctuations in IC-driven diseases.
Journal ArticleDOI
Life without peripheral serotonin: insights from tryptophan hydroxylase 1 knockout mice reveal the existence of paracrine/autocrine serotonergic networks.
TL;DR: The objective of this review is to highlight the newly discovered functions played by the monoamine using the Tph1 KO murine model and to outline current findings that led to the discovery of complete serotonergic systems in unexpected organs.