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Walter J. Loos
Researcher at Erasmus University Rotterdam
Publications - 142
Citations - 7735
Walter J. Loos is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Pharmacokinetics & Topotecan. The author has an hindex of 48, co-authored 142 publications receiving 7364 citations. Previous affiliations of Walter J. Loos include Erasmus University Medical Center.
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Journal Article
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11)
Ron H.J. Mathijssen,Robbert J. van Alphen,Jaap Verweij,Walter J. Loos,Kees Nooter,Gerrit Stoter,Alex Sparreboom +6 more
TL;DR: CPT-11 belongs to the class of topoisomerase I inhibitors, and it acts as a prodrug of SN-38, which is approximately 100-1000fold more cytotoxic than the parent drug as mentioned in this paper.
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Pharmacological effects of formulation vehicles : implications for cancer chemotherapy.
TL;DR: Kinetic experiments revealed that addition of CrEL to the formulation of oral drug preparations seems to result in significantly diminished drug uptake and reduced circulating concentrations, in contrast to the enhancing effects of Tween® 80.
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Effects of St. John's Wort on Irinotecan Metabolism
TL;DR: It is indicated that patients on irinotecan treatment should refrain from taking SJW because plasma levels of SN-38 were dramatically reduced, which may have a deleterious impact on treatment outcome.
Journal Article
Cremophor EL-mediated alteration of paclitaxel distribution in human blood: clinical pharmacokinetic implications.
Alex Sparreboom,Lia van Zuylen,Eric Brouwer,Walter J. Loos,Peter de Bruijn,Hans Gelderblom,Marrimuthoo Pillay,Kees Nooter,Gerrit Stoter,Jaap Verweij +9 more
TL;DR: The findings in the present study demonstrate a profound alteration of paclitaxel accumulation in erythrocytes caused by a trapping of the compound in CrEL micelles, thereby reducing the free drug fraction available for cellular partitioning.
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Drug transporters of platinum-based anticancer agents and their clinical significance
Herman Burger,Walter J. Loos,Karel Eechoute,Jaap Verweij,Ron H.J. Mathijssen,Erik A.C. Wiemer +5 more
TL;DR: The role of active platinum uptake and efflux systems as determinants of platinum sensitivity and -resistance and their contribution to platinum pharmacokinetics (PK) and pharmacodynamics (PD) is focused on.