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Ward Lutz
Researcher at Mayo Clinic
Publications - 21
Citations - 2118
Ward Lutz is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Calcitriol receptor & Receptor. The author has an hindex of 16, co-authored 21 publications receiving 2043 citations.
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Journal ArticleDOI
Dendritic cell modulation by 1α,25 dihydroxyvitamin D3 and its analogs: A vitamin D receptor-dependent pathway that promotes a persistent state of immaturity in vitro and in vivo
TL;DR: It is concluded that 1α,25(OH)2D3/VDR mediates physiologically relevant inhibition of DC maturity that is resistant to maturational stimuli and modulates antigen-specific immune responses in vivo.
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Centrosome hypertrophy in human breast tumors: Implications for genomic stability and cell polarity
TL;DR: Examining a set of 35 high grade human breast tumors shows that centrosomes of adenocarcinoma cells generally display abnormal structure, aberrant protein phosphorylation, and increased microtubule nucleating capacity in comparison to centrosome of normal breast epithelial and stromal tissues.
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Potent inhibition of dendritic cell differentiation and maturation by vitamin D analogs.
TL;DR: Inhibition of DC maturation and stimulatory function was absent in cultures from mice genetically lacking vitamin D receptors (VDR).
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Phosphorylation of centrin during the cell cycle and its role in centriole separation preceding centrosome duplication.
TL;DR: It is suggested that centrin phosphorylation signals the separation of centrosomes at prophase and implicates centrinosphorylation in centriole separation that normally precedes centrosome duplication.
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The interaction of the vitamin D receptor with nuclear receptor corepressors and coactivators
TL;DR: In comparison to TR, VDR exhibits relatively weak ligand-independent transcriptional silencing, but it possesses strong dimerization with RXR and lig and-induced binding to transcriptional coactivators.