V
Vy A. Phan
Researcher at Mayo Clinic
Publications - 12
Citations - 1365
Vy A. Phan is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Dendritic cell & Antigen presentation. The author has an hindex of 9, co-authored 11 publications receiving 1305 citations.
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Journal ArticleDOI
Dendritic cell modulation by 1α,25 dihydroxyvitamin D3 and its analogs: A vitamin D receptor-dependent pathway that promotes a persistent state of immaturity in vitro and in vivo
TL;DR: It is concluded that 1α,25(OH)2D3/VDR mediates physiologically relevant inhibition of DC maturity that is resistant to maturational stimuli and modulates antigen-specific immune responses in vivo.
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Potent inhibition of dendritic cell differentiation and maturation by vitamin D analogs.
TL;DR: Inhibition of DC maturation and stimulatory function was absent in cultures from mice genetically lacking vitamin D receptors (VDR).
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G1 and G2 cell-cycle arrest following microtubule depolymerization in human breast cancer cells
TL;DR: Observations provide evidence for coupling of premitotic cell-cycle progression to microtubule integrity in some breast cancer cell lines and suggest a potential explanation for the recently reported failure of some cancer cell Lines to undergo nocodazole-induced mitotic arrest despite intact mitotic checkpoint proteins.
Journal Article
Enhancing the Efficacy of a Weak Allogeneic Melanoma Vaccine by Viral Fusogenic Membrane Glycoprotein-mediated Tumor Cell-Tumor Cell Fusion
Emmanouela Linardakis,Andrew Bateman,Vy A. Phan,Atique U. Ahmed,Michael J. Gough,Kenneth R. Olivier,Richard B. Kennedy,Fiona Errington,Kevin J. Harrington,Alan Melcher,Richard G. Vile +10 more
TL;DR: The data suggest that the unique manner in which syncytia develop and die provides a highly effective pathway for tumor antigen release and presentation to the immune system and offers a novel mechanism by which cancer cell vaccines may be prepared for clinical use.
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A new genetic method to generate and isolate small, short-lived but highly potent dendritic cell--tumor cell hybrid vaccines
Vy A. Phan,Fiona Errington,S Chiat Cheong,Tim Kottke,Michael J. Gough,Sharon Altmann,Annick Brandenburger,Steve Emery,Scott E. Strome,Andrew Bateman,Bernard Bonnotte,Alan Melcher,Richard G. Vile +12 more
TL;DR: A new method to generate hybrid cell vaccines is described, based on gene transfer of a viral fusogenic membrane glycoprotein (FMG) into tumor cells, and incorporate a genetic method by which true hybrid formation can be unambiguously detected.