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Warren G. Young
Researcher at Scripps Research Institute
Publications - 26
Citations - 2030
Warren G. Young is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Hippocampal formation & Dentate gyrus. The author has an hindex of 18, co-authored 26 publications receiving 1946 citations. Previous affiliations of Warren G. Young include Torrey Pines Institute for Molecular Studies & Scripps Health.
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Journal ArticleDOI
Distribution of histone deacetylases 1-11 in the rat brain.
Ron S. Broide,Jeff M. Redwine,Najla Aftahi,Warren G. Young,Floyd E. Bloom,Christopher J. Winrow +5 more
TL;DR: In this paper, the authors performed comprehensive gene expression mapping of the 11 HDAC isoforms (HDAC1-11) (classes I, II, and IV) throughout the rat brain using high-resolution in situ hybridization (ISH) and imaging technology.
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Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: A magnetic resonance microscopy and stereologic analysis
Jeffrey M. Redwine,Barry E. Kosofsky,Russell E. Jacobs,Dora Games,John F. Reilly,John H. Morrison,Warren G. Young,Floyd E. Bloom +7 more
TL;DR: It is concluded that overexpression of APP and amyloid may initiate pathologic changes before the appearance of plaques, suggesting novel targets for the treatment of Alzheimer's disease and further reinforcing the need for early diagnosis and treatment.
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Adult mouse brain gene expression patterns bear an embryologic imprint
Matthew A. Zapala,Iiris Hovatta,Julie A. Ellison,Lisa Wodicka,Jo A. Del Rio,Richard S. Tennant,Wendy Tynan,Ron S. Broide,Rob Helton,Barbara S. Stoveken,Christopher J. Winrow,Daniel J. Lockhart,John F. Reilly,Warren G. Young,Floyd E. Bloom,David J. Lockhart,Carrolee Barlow +16 more
TL;DR: A gene expression-based brain map measuring gene expression patterns for 24 neural tissues covering the mouse central nervous system found that the adult brain bears a transcriptional "imprint" consistent with both embryological origins and classic evolutionary relationships.
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Parvalbumin-immunoreactive neurons in the neocortex are resistant to degeneration in Alzheimer's disease
TL;DR: The results suggest that paravalbumin-immunoreactive cells represent a neuronal subset resistant to degeneration, and further support the hypothesis that the pathological process in Alzheimer's disease involves specific neuronal subtypes with particular morphological and molecular characteristics.
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Differential regulation of amyloid-beta-protein mRNA expression within hippocampal neuronal subpopulations in Alzheimer disease
Gerald A. Higgins,David A. Lewis,S. Bahmanyar,D. Goldgaber,D. C. Gajdusek,Warren G. Young,John H. Morrison,Michael Wilson +7 more
TL;DR: The neuroanatomical distribution of amyloid-beta-protein mRNA within neuronal subpopulations of the hippocampal formation in the cynomolgus monkey, normal aged human, and patients with Alzheimer disease is mapped.