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Barry E. Kosofsky
Researcher at Cornell University
Publications - 118
Citations - 7601
Barry E. Kosofsky is an academic researcher from Cornell University. The author has contributed to research in topics: Prenatal cocaine exposure & Nucleus accumbens. The author has an hindex of 45, co-authored 118 publications receiving 7204 citations. Previous affiliations of Barry E. Kosofsky include Johns Hopkins University & Harvard University.
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Journal ArticleDOI
Dynamic functional imaging of relative cerebral blood volume during rat forepaw stimulation
Joseph B. Mandeville,John J. A. Marota,Barry E. Kosofsky,John R. Keltner,Ralph Weissleder,Bruce R. Rosen,Robert M. Weisskoff +6 more
TL;DR: Dynamic measurements of regional changes in cerebral blood volume (CBV) were performed in rat models of hypercarbia and focal neuronal activation using T2‐weighted imaging after injection of an intravascular contrast agent with a very long blood half‐life to suggest proportional changes in blood volume for capillaries and small veins.
Journal ArticleDOI
Regulation of immediate early gene expression and AP-1 binding in the rat nucleus accumbens by chronic cocaine
TL;DR: The data suggest that chronic cocaine treatment leads to a persistent increase in AP-1 binding activity, which may be involved in some of the physiological and behavioral aspects of cocaine addiction.
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The serotoninergic innervation of cerebral cortex: different classes of axon terminals arise from dorsal and median raphe nuclei.
TL;DR: It is concluded that 5‐HT axons in cortex may be subdivided into two distinct projections, in accord with other, recent data showing that the two axon types have different pharmacologic properties and are likely to be functionally different.
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Treatment of late infantile neuronal ceroid lipofuscinosis by CNS administration of a serotype 2 adeno-associated virus expressing CLN2 cDNA.
Stefan Worgall,Dolan Sondhi,Neil R. Hackett,Barry E. Kosofsky,Minal V. Kekatpure,Nurunisa Neyzi,Jonathan P. Dyke,Douglas Ballon,Linda Heier,Bruce M. Greenwald,Paul J. Christos,Madhu Mazumdar,Mark M. Souweidane,Michael G. Kaplitt,Ronald G. Crystal +14 more
TL;DR: Assessment of the primary outcome variable suggests a slowing of progression of LINCL in the treated children, and it is proposed that additional studies to assess the safety and efficacy of AAV-mediated gene therapy for LINCL are warranted.
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Mutations in the Gene Encoding KRIT1, a Krev-1/rap1a Binding Protein, Cause Cerebral Cavernous Malformations (CCM1)
Trilochan Sahoo,Eric W. Johnson,James W. Thomas,Peter M. Kuehl,Thomas L. Jones,Charles G. Dokken,Jeffrey W. Touchman,Carol J. Gallione,Shih-Queen Lee-Lin,Barry E. Kosofsky,Janice H. Kurth,David N. Louis,Gabrielle Mettler,Leslie Morrison,Antonio Gil-Nagel,Steven S Rich,Joseph M. Zabramski,Mark S. Boguski,EricD. Green,Douglas A. Marchuk +19 more
TL;DR: Identification of a common Mexican-American mutation has potential clinical significance for presymptomatic diagnosis of CCM in this population and data point to a key role for the Krev-1/rap1a signaling pathway in angiogenesis and cerebrovascular disease.