W
Wei-Dong Chen
Researcher at City of Hope National Medical Center
Publications - 22
Citations - 1851
Wei-Dong Chen is an academic researcher from City of Hope National Medical Center. The author has contributed to research in topics: Farnesoid X receptor & Medicine. The author has an hindex of 12, co-authored 13 publications receiving 1539 citations. Previous affiliations of Wei-Dong Chen include Henan University & Inner Mongolia Medical University.
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Journal ArticleDOI
Farnesoid X receptor antagonizes nuclear factor κB in hepatic inflammatory response
TL;DR: It is demonstrated that FXR is a negative modulator of nuclear factor κB (NF‐κB)–mediated hepatic inflammation and may contribute to the critical roles of FXR in hepatoprotection and suppression of hepatocarcinogenesis.
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The G‐Protein‐coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light‐chain enhancer of activated B cells (NF‐κB) in mice
TL;DR: It is demonstrated that TGR5 is a negative modulator of nuclear factor kappa light‐chain enhancer of activated B cells (NF‐κB)‐mediated inflammation and may serve as an attractive therapeutic tool for immune and inflammatory liver diseases.
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FXR: a metabolic regulator and cell protector.
TL;DR: This review summarizes the basic information of FXR but focuses on its new functions, suggesting that FXR has much broader roles than previously thought and also highlighting FXR as a drug target for multiple diseases.
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TGR5, Not Only a Metabolic Regulator
TL;DR: The findings highlight TGR5 as a potential drug target for different diseases, which include inflammatory response, cancer and liver regeneration, as well as metabolic regulation and its new functions.
Journal ArticleDOI
Promotion of liver regeneration/repair by farnesoid X receptor in both liver and intestine in mice.
Lisheng Zhang,Yan-Dong Wang,Wei-Dong Chen,Xichun Wang,Guiyu Lou,Nian Liu,Min Lin,Barry M. Forman,Wendong Huang +8 more
TL;DR: It is demonstrated that, in addition to the cell‐autonomous effect of hepatic FXR, the endocrine FGF15 pathway activated by FXR in intestine also participates in the promotion of liver regeneration/repair.