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Wei Gao
Researcher at Harbin Medical University
Publications - 74
Citations - 1329
Wei Gao is an academic researcher from Harbin Medical University. The author has contributed to research in topics: Cancer & Metastasis. The author has an hindex of 17, co-authored 67 publications receiving 749 citations. Previous affiliations of Wei Gao include Shanxi Medical University.
Papers
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Journal ArticleDOI
circPARD3 drives malignant progression and chemoresistance of laryngeal squamous cell carcinoma by inhibiting autophagy through the PRKCI-Akt-mTOR pathway
Wei Gao,Guo Huina,Min Niu,Zheng Xiwang,Yuliang Zhang,Xue Xuting,Yunfeng Bo,Guan Xiaoya,Li Zhongxun,Yujia Guo,Long He,Yu Zhang,Li Li,Jimin Cao,Yongyan Wu +14 more
TL;DR: This study reveals that the novel autophagy-suppressive circPARD3 promotes LSCC progression and chemoresistance through the PRKCI-Akt-mTOR pathway, providing new insights into circRNA-mediated autophagic regulation and potential biomarker and target for LSCC treatment.
Journal ArticleDOI
Promoter Methylation-Regulated miR-145-5p Inhibits Laryngeal Squamous Cell Carcinoma Progression by Targeting FSCN1.
Wei Gao,Chunming Zhang,Li Wenqi,Huizheng Li,Jiangwei Sang,Qinli Zhao,Yunfeng Bo,Hongjie Luo,Zheng Xiwang,Yan Lu,Yong Shi,Dongli Yang,Ruiping Zhang,Li Zhenyu,Jiajia Cui,Yuliang Zhang,Min Niu,Jun Li,Wu Zhongqiang,Guo Huina,Caixia Xiang,Juan Wang,Juan Hou,Lu Zhang,Rick F. Thorne,Rick F. Thorne,Yongping Cui,Yongyan Wu,Shuxin Wen,Binquan Wang +29 more
TL;DR: Gain- and loss-of-function studies showed that miR-145-5p overexpression or FSCN1 knockdown inhibited LSCC migration, invasion, and growth by suppressing the epithelial-mesenchymal transition along with inducing cell-cycle arrest and apoptosis.
Journal ArticleDOI
Circular RNA circCORO1C promotes laryngeal squamous cell carcinoma progression by modulating the let-7c-5p/PBX3 axis
Yongyan Wu,Yuliang Zhang,Zheng Xiwang,Dai Fengsheng,Yan Lu,Dai Li,Min Niu,Guo Huina,Li Wenqi,Xue Xuting,Yunfeng Bo,Yujia Guo,Jiangbo Qin,Yixiao Qin,Liu Hongliang,Yu Zhang,Tao Yang,Li Li,Linshi Zhang,Rui Hou,Shuxin Wen,Changming An,Huizheng Li,Xu Wei,Wei Gao +24 more
TL;DR: Mechanistic studies revealed that circCORO1C competitively bound to let-7c-5p and prevented it from decreasing the level of PBX3, which facilitated the malignant progression of LSCC and may serve as a novel target for LSCC therapy.
Journal ArticleDOI
c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis.
Yu Chen Feng,Xiao Ying Liu,Liu Teng,Qiang Ji,Yongyan Wu,Jinming Li,Wei Gao,Yuan Yuan Zhang,Ting La,Hessam Tabatabaee,Xu Guang Yan,M Fairuz B Jamaluddin,Didi Zhang,Su Tang Guo,Rodney J. Scott,Tao Liu,Rick F. Thorne,Rick F. Thorne,Xudong Zhang,Xudong Zhang,Lei Jin,Lei Jin +21 more
TL;DR: The results uncover an inhibitory axis targeting p53 through a pan-cancer expressed RNA accomplice that links c-Myc to suppression of p53.
Journal ArticleDOI
Crosstalk between RNA m6A Modification and Non-coding RNA Contributes to Cancer Growth and Progression.
Dai Fengsheng,Yongyan Wu,Yan Lu,Changming An,Zheng Xiwang,Dai Li,Yujia Guo,Linshi Zhang,Huizheng Li,Xu Wei,Wei Gao +10 more
TL;DR: The functional crosstalk between m6A and non-Coding RNAs, particularly microRNA, long non-coding RNA, and circular RNA, is described, and their roles in tumor regulation are illustrated.