Wei Gong

TL;DR: The data reveals that the pathway ‘HULC/USP22/Sirt1/ protective autophagy’ attenuates the sensitivity of HCC cells to chemotherapeutic agents, suggesting that this pathway may be a novel target for developing sensitizing strategy to HCC chemotherapy.

TL;DR: The results of the present study suggest that suppression of BAFF production may be a novel mechanism by which curcumin improves RA.

TL;DR: Modulation of SOCS3 expression may represent a novel mechanism through which FXR activation could selectively affect cytokine bioactivity in inflammation response.

TL;DR: Functional experiments showed that the FXR-mediated upregulation of miR-122 suppressed the proliferation of HCC cells in vitro and the growth of H CC xenografts in vivo, suggesting that FXR may serve as a key transcriptional regulator for manipulating mi R-122 expression, and theFXR/miR- 122 pathway may therefore be a novel target for the treatment of Hcc.

TL;DR: It is demonstrated that specific LXRs agonists downregulated expression of FOXM1, cyclin D1 and cyclin B1 in hepatocellular carcinoma (HCC) cells, which led to cell cycle and cell proliferation arrest, suggesting that the pathway may be a novel target for HCC treatment.