Wei He

TL;DR: Gold nanorods excited at 830 nm on a far-field laser-scanning microscope produced strong two-photon luminescence (TPL) intensities, with a cos(4) dependence on the incident polarization.

TL;DR: In vivo Forster resonance energy transfer imaging was employed to monitor the release of hydrophobic molecules from circulating poly(ethylene glycol)-poly( D, L-lactic acid) (PEG-PDLLA) micelles, and demonstrated that alpha- and beta-globulins were major factors for the observed fast release.

TL;DR: Analysis of whole blood samples from cancer patients establishes that human CTCs can be selectively labeled and quantitated when present at ≈2 CTCS per ml, opening opportunities for earlier assessment of metastatic disease.

TL;DR: Fluorescent conjugates of 2 high‐affinity tumor‐specific ligands that bind tumor cells >20‐fold more efficiently than fluorescent antibodies are synthesized that can be exploited for quantitation of CTCs in peripheral blood samples from cancer patients.

TL;DR: A novel method capable of monitoring the pharmacokinetics of PEGylated gold nanorods (GNRs) in the same animal by using intravital two-photon luminescence (TPL) imaging of GNRs flowing through a surface blood vessel is presented.