W
Wei-Lien Chuang
Researcher at Genzyme
Publications - 44
Citations - 1863
Wei-Lien Chuang is an academic researcher from Genzyme. The author has contributed to research in topics: Acid sphingomyelinase & Glucocerebrosidase. The author has an hindex of 23, co-authored 44 publications receiving 1652 citations. Previous affiliations of Wei-Lien Chuang include University of California, Riverside.
Papers
More filters
Journal ArticleDOI
Glucocerebrosidase gene-deficient mouse recapitulates Gaucher disease displaying cellular and molecular dysregulation beyond the macrophage.
Pramod K. Mistry,Jun Liu,Mei Yang,Timothy Nottoli,James L. McGrath,Dhanpat Jain,Kate Zhang,Joan Keutzer,Wei-Lien Chuang,Wajahat Z. Mehal,Hongyu Zhao,Aiping Lin,Shrikant Mane,Xuan Liu,Yuan Z. Peng,Jian H. Li,Manasi Agrawal,Ling-Ling Zhu,Harry C. Blair,Lisa J. Robinson,Jameel Iqbal,Li Sun,Mone Zaidi +22 more
TL;DR: Direct evidence is provided for the involvement in GD1 of multiple cell lineages, suggesting that cells other than macrophages may be worthwhile therapeutic targets.
Journal ArticleDOI
A specific and potent inhibitor of glucosylceramide synthase for substrate inhibition therapy of Gaucher disease
Kerry Anne McEachern,John J. Fung,Svetlana Komarnitsky,Craig Siegel,Wei-Lien Chuang,Elizabeth Hutto,James A. Shayman,Gregory A. Grabowski,Johannes M. F. G. Aerts,Seng H. Cheng,Diane Copeland,John Marshall +11 more
TL;DR: Biochemical characterization and data indicate that substrate inhibition therapy with Genz-112638 represents a viable alternate approach to enzyme therapy to treat the visceral pathology in Gaucher disease.
Journal ArticleDOI
Multiplex Enzyme Assay Screening of Dried Blood Spots for Lysosomal Storage Disorders by Using Tandem Mass Spectrometry
X. Kate Zhang,Carole Elbin,Wei-Lien Chuang,Samantha Cooper,Carla Marashio,Christa Beauregard,Joan Keutzer +6 more
TL;DR: The modified multiplex enzyme assay with premixed S and IS is appropriate for use in high-throughput screening laboratories and shows higher precision than the original method.
Journal ArticleDOI
Glucosylsphingosine is a key Biomarker of Gaucher Disease
Vagishwari Murugesan,Wei-Lien Chuang,Jun Liu,Andrew Lischuk,Katherine Kacena,Haiqun Lin,Gregory M. Pastores,Ruhua Yang,Joan Keutzer,Kate Zhang,Pramod K. Mistry +10 more
TL;DR: This study assessed plasma Lyso‐GL1 as a biomarker of GD and its response to therapy and its role in mediating immune dysregulation and skeletal disease.
Journal ArticleDOI
Glucocerebrosidase 2 gene deletion rescues type 1 Gaucher disease
Pramod K. Mistry,Jun Liu,Li Sun,Wei-Lien Chuang,Tony Yuen,Tony Yuen,Ruhua Yang,Ping Lu,Kate Zhang,Jianhua Li,Joan Keutzer,Agnes Stachnik,Albert Mennone,James L. Boyer,Dhanpat Jain,Roscoe O. Brady,Maria I New,Maria I New,Mone Zaidi +18 more
TL;DR: The authors showed that deletion of Gba2 significantly rescues the GD1 clinical phenotype, despite enhanced elevations in glucosylceramide (GL-1) and Lysogl-1.