W
Wei-Ping Yang
Researcher at Scripps Research Institute
Publications - 5
Citations - 1027
Wei-Ping Yang is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Phage display & Binding site. The author has an hindex of 5, co-authored 5 publications receiving 1009 citations.
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Journal ArticleDOI
CDR Walking Mutagenesis for the Affinity Maturation of a Potent Human Anti-HIV-1 Antibody into the Picomolar Range
Wei-Ping Yang,Kimberly Green,Sally Pinz-Sweeney,Amelia T. Briones,Dennis R. Burton,Carlos F. Barbas +5 more
TL;DR: The methodology presented here provides a route for the improvement of the affinities of antibodies typical of tertiary immune responses into the picomolar range and may have profound effects on the utility of antibodies as therapeutic and prophylactic agents.
Journal ArticleDOI
Building zinc fingers by selection : toward a therapeutic application
TL;DR: A phage display approach was utilized to modify the specificity of each of the three fingers of the murine transcription factor Zif268, and no evidence in support of a single general coding relationship between zinc finger and target DNA sequence was observed.
Journal Article
Neutralizing recombinant human antibodies to a conformational V2- and CD4-binding site-sensitive epitope of HIV-1 gp120 isolated by using an epitope-masking procedure.
Henrik J. Ditzel,James M. Binley,John P. Moore,Joseph Sodroski,Nancy J. Sullivan,Lynette S. W. Sawyer,R. M. Hendry,Wei-Ping Yang,Carlos F. Barbas,Dennis R. Burton +9 more
TL;DR: Results indicate the presence of a novel neutralizing conformational epitope on gp120 sensitive to the V2 loop and the CD4bs and further highlight the conformational flexibility of gp120.
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In vitro antigen challenge of human antibody libraries for vaccine evaluation: the human immunodeficiency virus type 1 envelope.
Paul W. H. I. Parren,Paola Fisicaro,Aran F. Labrijn,James M. Binley,Wei-Ping Yang,Henrik J. Ditzel,Carlos F. Barbas,Dennis R. Burton +7 more
TL;DR: It is concluded that recombinant gp160, gp140, and, to a lesser extent, gp120 present epitopes around the CD4 binding site in a conformation different from that of the native multimer and contrary to expected vaccine requirements.
Journal ArticleDOI
Surface plasmon resonance based kinetic studies of zinc finger-DNA interactions
TL;DR: Wu et al. as discussed by the authors constructed a zinc finger DNA binding protein, Zif268, and selected for affinity and specificity toward DNA targets using the phage display technique using a real-time biomolecular interaction assay (BIA).