W
Wei Wu
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 3
Citations - 262
Wei Wu is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Gene & Epigenomics. The author has an hindex of 3, co-authored 3 publications receiving 152 citations.
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Journal ArticleDOI
Mutant-IDH1-dependent chromatin state reprogramming, reversibility, and persistence
Sevin Turcan,Sevin Turcan,Vladimir Makarov,Julian Taranda,Yuxiang Wang,Armida W. M. Fabius,Armida W. M. Fabius,Wei Wu,Yupeng Zheng,Nour El-Amine,Sara Haddock,Sara Haddock,Gouri Nanjangud,H. Carl Lekaye,Cameron Brennan,Justin R. Cross,Jason T. Huse,Neil L. Kelleher,Pavel Osten,Craig B. Thompson,Timothy A. Chan,Timothy A. Chan +21 more
TL;DR: This study uses human astrocytes and glioma tumorspheres to generate an atlas of mutant-IDH1-induced epigenomic reprogramming and discovers genome-wide coordinate changes in the localization and intensity of multiple histone marks and chromatin states.
Journal ArticleDOI
Mutations in BRCA1 and BRCA2 differentially affect the tumor microenvironment and response to checkpoint blockade immunotherapy
Robert M. Samstein,Robert M. Samstein,Robert M. Samstein,Chirag Krishna,Xiaoxiao Ma,Xin Pei,Ken-Wing Lee,Vladimir Makarov,Fengshen Kuo,Jonathan H. Chung,Raghvendra M. Srivastava,Tanaya A. Purohit,Douglas R. Hoen,Rajarsi Mandal,Jeremy Setton,Wei Wu,Rachna Shah,Besnik Qeriqi,Qing Chang,Sviatoslav M. Kendall,Lior Z. Braunstein,Britta Weigelt,Pedro Blecua Carrillo Albornoz,Luc G. T. Morris,Diana Mandelker,Jorge S. Reis-Filho,Elisa de Stanchina,Simon N. Powell,Timothy A. Chan,Nadeem Riaz +29 more
TL;DR: In this paper, the effects of mutations in the homologous recombination genes BRCA1 and bRCA2 on response to immunotherapy in mouse and human tumors were investigated.
Journal ArticleDOI
Integrated Genomics for Pinpointing Survival Loci within Arm-Level Somatic Copy Number Alterations
David M. Roy,Logan A. Walsh,Alexis Desrichard,Jason T. Huse,Wei Wu,Jianjiong Gao,Promita Bose,William Lee,Timothy A. Chan +8 more
TL;DR: This comprehensive approach uncovered several 9p loss-specific prognostic markers, validated existing ones, and redefined the impact of CDKN2A loss in LGG.