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Wei Xiao
Researcher at Capital Normal University
Publications - 253
Citations - 7227
Wei Xiao is an academic researcher from Capital Normal University. The author has contributed to research in topics: DNA damage & DNA repair. The author has an hindex of 43, co-authored 208 publications receiving 6576 citations. Previous affiliations of Wei Xiao include University of Saskatchewan & Harvard University.
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Journal ArticleDOI
Bcl10 activates the NF-κB pathway through ubiquitination of NEMO
Honglin Zhou,Ingrid E. Wertz,Ingrid E. Wertz,Karen O'Rourke,Mark Ultsch,Somasekar Seshagiri,Michael Eby,Wei Xiao,Vishva M. Dixit +8 more
TL;DR: The adaptor protein Bcl10 promotes activation of NF-κB transcription factors through paracaspase- and UBC13-dependent ubiquitination of NEMO.
Journal ArticleDOI
MMS2, encoding a ubiquitin-conjugating-enzyme-like protein, is a member of the yeast error-free postreplication repair pathway
TL;DR: It is proposed that the mms2 null mutation and two other allele-specific mutations, rad6Delta1-9 and pol30-46, define the error-free mode of DNA postreplication repair, and that these mutations may enhance both spontaneous and DNA damage-induced mutagenesis.
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DNA postreplication repair and mutagenesis in Saccharomyces cerevisiae.
TL;DR: The PRR processes appear to be highly conserved within eukaryotes, from yeast to human, and are also genetically regulated by a DNA helicase and are coupled to the cell-cycle.
Journal ArticleDOI
Eukaryotic DNA damage tolerance and translesion synthesis through covalent modifications of PCNA.
TL;DR: Interestingly, in budding yeast, these two pathways are mediated by sequential modifications of the proliferating cell nuclear antigen by two ubiquitination complexes Rad6-Rad18 and Mms2-Ubc13-Rad5, which promote error-free lesion bypass and increased mutagenesis.
Journal ArticleDOI
Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A.
Parker L. Andersen,Honglin Zhou,Landon Pastushok,Trevor F. Moraes,Sean A. McKenna,Barry Ziola,Michael J. Ellison,Vishva M. Dixit,Wei Xiao +8 more
TL;DR: It is demonstrated that divergent activities of mammalian Ubc13 rely on its pairing with either of two Uevs, Uev1A or Mms2, and this finding suggests a novel regulatory mechanism in which differentUevs direct Ubcs to diverse cellular processes through physical interaction and alternative polyubiquitination.