H
Honglin Zhou
Researcher at Tsinghua University
Publications - 29
Citations - 6266
Honglin Zhou is an academic researcher from Tsinghua University. The author has contributed to research in topics: Inverter & Rotor (electric). The author has an hindex of 19, co-authored 29 publications receiving 5945 citations. Previous affiliations of Honglin Zhou include Merck & Co. & University of Pennsylvania.
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Journal ArticleDOI
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling
Ingrid E. Wertz,Karen O'Rourke,Honglin Zhou,Michael Eby,L. Aravind,Somasekar Seshagiri,Ping Wu,Christian Wiesmann,Rohan T. Baker,David L. Boone,Averil Ma,Eugene V. Koonin,Vishva M. Dixit +12 more
TL;DR: A novel ubiquitin ligase domain is defined and two sequential mechanisms by which A20 downregulates NF-κB signalling are identified, both of which participate in mediating a distinct regulatory effect.
Journal ArticleDOI
Genome-Scale RNAi Screen for Host Factors Required for HIV Replication
Honglin Zhou,Min Xu,Qian Huang,Adam Gates,Xiaohua Douglas Zhang,John C. Castle,Erica Stec,Marc Ferrer,Berta Strulovici,Daria J. Hazuda,Amy S. Espeseth +10 more
TL;DR: In this article, the authors conducted a genome-scale siRNA screen, revealing more than 311 host factors, including 267 that were not previously linked to HIV, and found that there was little overlap between these genes and the HIV dependency factors described recently.
Journal ArticleDOI
Bcl10 activates the NF-κB pathway through ubiquitination of NEMO
Honglin Zhou,Ingrid E. Wertz,Ingrid E. Wertz,Karen O'Rourke,Mark Ultsch,Somasekar Seshagiri,Michael Eby,Wei Xiao,Vishva M. Dixit +8 more
TL;DR: The adaptor protein Bcl10 promotes activation of NF-κB transcription factors through paracaspase- and UBC13-dependent ubiquitination of NEMO.
Journal ArticleDOI
Akt regulates cell survival and apoptosis at a postmitochondrial level.
TL;DR: It is shown that stable expression of either constitutively active Akt or Bcl-2 inhibits apoptosis, but only B cl-2 prevents the release of cytochrome c from mitochondria, suggesting that Akt regulates apoptosis at a postmitochondrial level.
Journal ArticleDOI
Host Cell Factors in HIV Replication: Meta-Analysis of Genome-Wide Studies
Frederic D. Bushman,Nirav Malani,Jason D Fernandes,Jason D Fernandes,Iván D'Orso,Iván D'Orso,Gerard Cagney,Gerard Cagney,Gerard Cagney,Tracy L. Diamond,Honglin Zhou,Daria J. Hazuda,Amy S. Espeseth,Renate König,Sourav Bandyopadhyay,Trey Ideker,Stephen P. Goff,Nevan J. Krogan,Nevan J. Krogan,Alan D. Frankel,Alan D. Frankel,John A. T. Young,Sumit K. Chanda +22 more
TL;DR: An “encyclopedia” of all overlaps between studies yielded a more extensively corroborated set of host factors assisting HIV replication, and refined networks that specify cellular subsystems recruited by HIV to assist in replication are reported.