Wei Xie

TL;DR: It is shown that expression of Hoxc genes is sufficient to reprogram mesenchymal DP cells and alter the regenerative potential of epithelial stem cells and promote regional HF regeneration through canonical Wnt signaling.

TL;DR: The comprehensive profiling of the epigenome and transcriptome throughout the lineage commitment and differentiation of C3H10T1/2 mesenchymal stem cell line intobrown adipocytes finds that in brown adipocytes, brown lineage-specific genes are pre-marked by both H3K4me1 and H3k27me3, and the removal of H3 k27me1 at the late stage is necessary but not sufficient to promote brown gene expression.

TL;DR: Recent progress in understanding epigenetic reprogramming and their functions during mammalian early development is discussed and the conserved and species-specific principles underlying diverse regulation of the epigenome in early embryos during evolution are highlighted.

TL;DR: In this article, self-renewing formative pluripotent stem cells (fPSCs) were established from different mouse ESCs, pre-/early-gastrula epiblasts and induced PSCs.

TL;DR: A versatile library construction method that can be applied to both ChIP-seq and RNA-seq on the widely used Illumina platforms, which has wide applications in genomic, epigenomic, transcriptomic and interactomic studies.