W
Wei Yan
Researcher at University of Texas Southwestern Medical Center
Publications - 2
Citations - 124
Wei Yan is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: GTP' & Heterotrimeric G protein. The author has an hindex of 2, co-authored 2 publications receiving 72 citations.
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Journal ArticleDOI
Tissue-Specific Oncogenic Activity of KRASA146T
Emily J. Poulin,Emily J. Poulin,Asim K. Bera,Jia Lu,Yi Jang Lin,Yi Jang Lin,Samantha Dale Strasser,Samantha Dale Strasser,Joao A. Paulo,Tannie Q. Huang,Carolina Morales,Wei Yan,Joshua Cook,Joshua Cook,Jonathan A. Nowak,Douglas K. Brubaker,Douglas K. Brubaker,Douglas K. Brubaker,Brian A. Joughin,Christian W. Johnson,Christian W. Johnson,Rebecca A. Destefanis,Rebecca A. Destefanis,Phaedra C. Ghazi,Phaedra C. Ghazi,Sudershan R. Gondi,Thomas E. Wales,Roxana E. Iacob,Lana Bogdanova,Jessica J. Gierut,Jessica J. Gierut,Yina Li,Yina Li,John R. Engen,Pedro A. Perez-Mancera,Benjamin S. Braun,Steven P. Gygi,Douglas A. Lauffenburger,Kenneth D. Westover,Kevin M. Haigis,Kevin M. Haigis +40 more
TL;DR: It is demonstrated that the selection for specific KRAS mutants in human cancers from different tissues is due to their distinct signaling properties, demonstrating that context-dependent variations in signaling downstream of differentKRAS mutants drive the KRAS mutational pattern seen in cancer.
Journal ArticleDOI
GTP hydrolysis is modulated by Arg34 in the RASopathy-associated KRASP34R.
Asim K. Bera,Jia Lu,Chunya Lu,Chunya Lu,Lianbo Li,Sudershan R. Gondi,Wei Yan,Andrew Nelson,Goujun Zhang,Kenneth D. Westover +9 more
TL;DR: High-resolution X-ray structures of the RASopathy mutant KRASP34R are determined, finding that GTP-bound conformations are compatible with intrinsic nucleotide hydrolysis, including one that places R34 in a position analogous to the GAP arginine finger or intrinsic arginin finger found in heterotrimeric G proteins, which may support intrinsic GTP Hydrolysis.