J
Jonathan A. Nowak
Researcher at Brigham and Women's Hospital
Publications - 156
Citations - 9164
Jonathan A. Nowak is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Colorectal cancer & Cancer. The author has an hindex of 36, co-authored 116 publications receiving 6490 citations. Previous affiliations of Jonathan A. Nowak include Aix-Marseille University & Howard Hughes Medical Institute.
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Journal ArticleDOI
Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma
Marios Giannakis,Marios Giannakis,Marios Giannakis,Xinmeng Jasmine Mu,Xinmeng Jasmine Mu,Xinmeng Jasmine Mu,Sachet A. Shukla,Sachet A. Shukla,Zhi Rong Qian,Ofir Cohen,Ofir Cohen,Reiko Nishihara,Samira Bahl,Yin Cao,Ali Amin-Mansour,Ali Amin-Mansour,Mai Yamauchi,Yasutaka Sukawa,Chip Stewart,Mara Rosenberg,Kosuke Mima,Kentaro Inamura,Katsuhiko Nosho,Jonathan A. Nowak,Michael S. Lawrence,Edward Giovannucci,Edward Giovannucci,Andrew T. Chan,Andrew T. Chan,Kimmie Ng,Kimmie Ng,Jeffrey A. Meyerhardt,Jeffrey A. Meyerhardt,Eliezer M. Van Allen,Eliezer M. Van Allen,Eliezer M. Van Allen,Gad Getz,Gad Getz,Stacey Gabriel,Eric S. Lander,Eric S. Lander,Eric S. Lander,Catherine J. Wu,Catherine J. Wu,Catherine J. Wu,Charles S. Fuchs,Charles S. Fuchs,Shuji Ogino,Shuji Ogino,Levi A. Garraway,Levi A. Garraway,Levi A. Garraway +51 more
TL;DR: It was found that higher neoantigen load was positively associated with overall lymphocytic infiltration, tumor-infiltrating lymphocytes, memory T cells, and CRC-specific survival and positive selection of mutations in HLA genes and other components of the antigen-processing machinery in TIL-rich tumors.
Journal ArticleDOI
Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis
Kosuke Mima,Reiko Nishihara,Zhi Rong Qian,Yin Cao,Yasutaka Sukawa,Jonathan A. Nowak,Juhong Yang,Juhong Yang,Ruoxu Dou,Yohei Masugi,Mingyang Song,Aleksandar Kostic,Aleksandar Kostic,Marios Giannakis,Marios Giannakis,Marios Giannakis,Susan Bullman,Susan Bullman,Danny A. Milner,Danny A. Milner,Hideo Baba,Edward Giovannucci,Edward Giovannucci,Levi A. Garraway,Levi A. Garraway,Levi A. Garraway,Gordon J. Freeman,Gordon J. Freeman,Glenn Dranoff,Glenn Dranoff,Wendy S. Garrett,Wendy S. Garrett,Curtis Huttenhower,Curtis Huttenhower,Matthew Meyerson,Matthew Meyerson,Matthew Meyerson,Jeffrey A. Meyerhardt,Andrew T. Chan,Andrew T. Chan,Charles S. Fuchs,Charles S. Fuchs,Shuji Ogino,Shuji Ogino +43 more
TL;DR: The amount of F. nucleatum DNA in colorectal cancer tissue is associated with shorter survival, and may potentially serve as a prognostic biomarker, which may have implications in developing cancer prevention and treatment strategies through targeting GI microflora by diet, probiotics and antibiotics.
Journal ArticleDOI
Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development.
Meritxell Gironella,Mylène Seux,Min-Jue Xie,Carla E. Cano,Richard Tomasini,Julien Gommeaux,Stéphane Garcia,Jonathan A. Nowak,Man Lung Yeung,Kuan-Teh Jeang,Amandine Chaix,Ladan Fazli,Yoshiharu Motoo,Qing Wang,Palma Rocchi,Antonio Russo,Martin E. Gleave,Jean-Charles Dagorn,Juan L. Iovanna,Alice Carrier,Marie-Josèphe Pébusque,Nelson Dusetti +21 more
TL;DR: It is shown by immunohistochemical analysis that TP53INP1 expression is dramatically reduced in pancreatic ductal adenocarcinoma (PDAC) and this decrease occurs early during pancreatic cancer development and a previously unknown miR-155 target presenting anti-tumoral activity is presented.
Journal ArticleDOI
Hair Follicle Stem Cells are Specified and Function in Early Skin Morphogenesis
TL;DR: It is shown that slow-cycling cells appear early in skin development, express SC markers, and later give rise to the adult SC population, which establishes the existence of early hair follicle SCs and reveals their physiological importance in tissue morphogenesis.
Journal ArticleDOI
Fusobacterium nucleatum and T Cells in Colorectal Carcinoma.
Kosuke Mima,Yasutaka Sukawa,Reiko Nishihara,Zhi Rong Qian,Mai Yamauchi,Kentaro Inamura,Kentaro Inamura,Sun A. Kim,Atsuhiro Masuda,Jonathan A. Nowak,Katsuhiko Nosho,Aleksandar Kostic,Aleksandar Kostic,Marios Giannakis,Marios Giannakis,Hideo Watanabe,Hideo Watanabe,Susan Bullman,Susan Bullman,Danny A. Milner,Danny A. Milner,Curtis C. Harris,Edward Giovannucci,Levi A. Garraway,Levi A. Garraway,Gordon J. Freeman,Gordon J. Freeman,Glenn Dranoff,Glenn Dranoff,Andrew T. Chan,Andrew T. Chan,Wendy S. Garrett,Wendy S. Garrett,Curtis Huttenhower,Curtis Huttenhower,Charles S. Fuchs,Charles S. Fuchs,Shuji Ogino,Shuji Ogino +38 more
TL;DR: The human population data may provide an impetus for further investigations on potential interactive roles of Fusobacterium and host immunity in colon carcinogenesis, and the amount of tissue F nucleatum is inversely associated with CD3+ T-cell density in colorectal carcinoma tissue.