Weibao Qiu

TL;DR: In this article, the state-of-the-art in piezoelectric single crystals for ultrasonic transducer applications is reviewed, and various biomedical applications including eye imaging, intravascular imaging, blood flow measurement, photoacoustic imaging and microbeam applications of the single crystal transducers are discussed.

TL;DR: Because MscL opens to tension in the lipid bilayer, requiring no other proteins or ligands, it could be developed into a general noninvasive sonogenetic tool to manipulate the activities of neurons or other cells and potential nanodevices.

TL;DR: It is found that ultrasound alone could activate heterologous and endogenous Piezo1, initiating calcium influx and increased nuclear c-Fos expression in primary neurons but not when pre-treated with aPiezo1 inhibitor.

TL;DR: Dual-modal photoacoustic imaging and single-photon-emission computed tomography imaging based on ultrasmall Cu2- xSe nanoparticles were used to noninvasively monitor the opening and recovery of the blood-brain barrier induced by focused ultrasound in living mice and indicate that the accumulated Cu 2- x Se nanoparticles could be excreted from the brain and other major organs after 15 days without causing side effects.

TL;DR: High frequency (5 MHz) ultrasound can successfully activate the brain circuits in mice and provides a smaller stimulation region, which offers improved anatomical specificity for neuro-stimulation in a non-invasive manner.