W
Wen-Li Wei
Researcher at University of Toronto
Publications - 4
Citations - 1156
Wen-Li Wei is an academic researcher from University of Toronto. The author has contributed to research in topics: Extracellular & Dopamine receptor. The author has an hindex of 4, co-authored 4 publications receiving 1088 citations.
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Journal ArticleDOI
Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels.
Zhi-Gang Xiong,Xiao-Man Zhu,Xiang-Ping Chu,Manabu Minami,Jessica G. Hey,Wen-Li Wei,John F. MacDonald,John A. Wemmie,John A. Wemmie,John A. Wemmie,Margaret P. Price,Michael J. Welsh,Roger P. Simon +12 more
TL;DR: It is shown that acidosis activates Ca2+ -permeable acid-sensing ion channels (ASICs), inducing glutamate receptor-independent, Ca2-dependent, neuronal injury inhibited by ASIC blockers, and disclosing new potential therapeutic targets for stroke.
Journal ArticleDOI
TRPM7 channels in hippocampal neurons detect levels of extracellular divalent cations
Wen-Li Wei,Hong-Shuo Sun,Michelle E. Olah,Xiujun Sun,Elzbieta Czerwinska,Waldemar Czerwinski,Yasuo Mori,Beverley A. Orser,Zhi-Gang Xiong,Michael F. Jackson,Michael Tymianski,John F. MacDonald +11 more
TL;DR: The results demonstrate that TRPM7 contributes to the mechanism by which hippocampal neurons “detect” reductions in extracellular divalents and provide a means by which TRPM8 contributes to neuronal death during transient brain ischemia.
Journal ArticleDOI
D2-class dopamine receptor inhibition of NMDA currents in prefrontal cortical neurons is platelet-derived growth factor receptor-dependent.
Michael A. Beazely,Andrew Tong,Wen-Li Wei,Hubert H.M. Van Tol,Bikram Sidhu,John F. MacDonald +5 more
TL;DR: The finding suggest that quinpirole treatment inhibits NMDAR signaling via PDGF receptor transactivation in both the hippocampus and the PFC, and that the effects of quinPirole in these regions are mediated by D4 and D2/3 dopamine receptors, respectively.
Journal ArticleDOI
Acidosis decreases low Ca2+ -induced neuronal excitation by inhibiting the activity of calcium-sensing cation channels in cultured mouse hippocampal neurons
Xiang-Ping Chu,Xiao-Man Zhu,Wen-Li Wei,Guo‐Hua Li,Roger P. Simon,John F. MacDonald,Zhi-Gang Xiong +6 more
TL;DR: The results indicate that acidosis may inhibit low [Ca2+]o‐induced neuronal excitation by inhibiting the activity of the csNSC channels.