R
Raffaello Cimbro
Researcher at Johns Hopkins University School of Medicine
Publications - 37
Citations - 1634
Raffaello Cimbro is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Receptor & Neurodegeneration. The author has an hindex of 20, co-authored 34 publications receiving 1330 citations. Previous affiliations of Raffaello Cimbro include National Institutes of Health & Johns Hopkins University.
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Journal ArticleDOI
Local Cues Establish and Maintain Region-Specific Phenotypes of Basal Ganglia Microglia
Lindsay M. De Biase,Kornel E. Schuebel,Zachary H. Fusfeld,Kamwing Jair,Isobel A. Hawes,Raffaello Cimbro,Hai Ying Zhang,Qing-Rong Liu,Hui Shen,Zheng-Xiong Xi,David Goldman,Antonello Bonci,Antonello Bonci +12 more
TL;DR: It is shown that microglial anatomical features, lysosome content, membrane properties, and transcriptomes differ significantly across BG nuclei, and region-specific phenotypes of BG microglia emerged during the second postnatal week and were re-established following genetic or pharmacologicalmicroglial ablation and repopulation in the adult.
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Sustained virologic control in SIV+ macaques after antiretroviral and α4β7 antibody therapy
Siddappa N. Byrareddy,James Arthos,Claudia Cicala,Francois Villinger,Kristina Ortiz,Dawn M. Little,Neil Sidell,Maureen A. Kane,Jianshi Yu,Jace W. Jones,Philip J. Santangelo,Chiara Zurla,Lyle R. McKinnon,Kelly B. Arnold,Caroline E. Woody,Lutz Walter,Christian Roos,Angela Noll,Donald Van Ryk,Katija Jelicic,Raffaello Cimbro,Sanjeev Gumber,Michelle D. Reid,Volkan Adsay,Praveen K. Amancha,Ann E. Mayne,Tristram G. Parslow,Anthony S. Fauci,Aftab A. Ansari +28 more
TL;DR: Combining short-term antiretroviral therapy with specific anti-integrin treatment sustains low viral loads in monkeys and allows macaques to effectively control viremia and reconstitute their immune systems without a need for further therapy.
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Incubation of Methamphetamine Craving Is Associated with Selective Increases in Expression of Bdnf and Trkb, Glutamate Receptors, and Epigenetic Enzymes in Cue-Activated Fos-Expressing Dorsal Striatal Neurons
Xuan Li,F. Javier Rubio,Tamara Zeric,Jennifer M. Bossert,Sarita Kambhampati,Hannah M. Cates,Pamela J. Kennedy,Qing-Rong Liu,Raffaello Cimbro,Bruce T. Hope,Eric J. Nestler,Yavin Shaham +11 more
TL;DR: Results demonstrate a critical role of DS in incubation of methamphetamine craving and that this incubation is associated with selective gene-expression alterations in cue-activated D1- and D2-expressing DS neurons.
Journal ArticleDOI
Glycosylation, Hypogammaglobulinemia, and Resistance to Viral Infections
Mohammed A. Sadat,Susan Moir,Tae-Wook Chun,Paolo Lusso,Gerardo G. Kaplan,Lynne A. Wolfe,Matthew J. Memoli,Miao He,Hugo Vega,Yan Huang,Nadia Hussein,Elma Nievas,Raquel Mitchell,Mary Garofalo,Aaron Louie,Derek C. Ireland,Claire Grunes,Raffaello Cimbro,Vyomesh Patel,Genevieve Holzapfel,Daniel Salahuddin,Tyler Bristol,David H. Adams,Beatriz E. Marciano,Madhuri Hegde,Yuxing Li,Katherine R. Calvo,Jennifer Stoddard,J. Shawn Justement,Jerome Jacques,Debra A. Long Priel,Danielle Murray,Peter D. Sun,Douglas B. Kuhns,Cornelius F. Boerkoel,John A. Chiorini,Daniela Verthelyi,Sergio D. Rosenzweig +37 more
TL;DR: A shortened immunoglobulin half-life was determined to be the mechanism underlying the hypogammaglobulinemia and impaired viral replication and cellular entry may explain a decreased susceptibility to infections.
Journal ArticleDOI
Identification of the platelet-derived chemokine CXCL4/PF-4 as a broad-spectrum HIV-1 inhibitor
David J. Auerbach,Yin Lin,Huiyi Miao,Raffaello Cimbro,Michelle J. DiFiore,Monica E. Gianolini,Lucinda Furci,Priscilla Biswas,Anthony S. Fauci,Paolo Lusso +9 more
TL;DR: It is shown that the CXC chemokine CXCL4 (PF-4), the most abundant protein contained within the α-granules of platelets, is a broad-spectrum inhibitor of HIV-1 infection, consistent with the lack of viral phenotype specificity.