W
Wengen Chen
Researcher at University of Maryland, Baltimore
Publications - 107
Citations - 5586
Wengen Chen is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Positron emission tomography & Fluorodeoxyglucose. The author has an hindex of 32, co-authored 102 publications receiving 5029 citations. Previous affiliations of Wengen Chen include Huazhong University of Science and Technology & Hospital of the University of Pennsylvania.
Papers
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ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins
TL;DR: ABCG1 is highly expressed in macrophages and probably mediates cholesterol efflux from macrophage foam cells to the major HDL fractions, providing a mechanism to explain the relationship between HDL levels and atherosclerosis risk.
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HDL from CETP-deficient subjects shows enhanced ability to promote cholesterol efflux from macrophages in an apoE- and ABCG1-dependent pathway
TL;DR: CETP-D HDL has enhanced ability to promote cholesterol efflux from foam cells in an ABCG1-dependent pathway due to an increased content of LCAT and apoE, and increased cholesterol esterification activity resided within the apOE-HDL fraction.
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A PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA-I
Nan Wang,Wengen Chen,Patrick Linsel-Nitschke,Laurent O. Martinez,Birgit Agerholm-Larsen,David L. Silver,Alan R. Tall +6 more
TL;DR: A novel mode of regulation of ABCA1 by PEST sequence-mediated calpain proteolysis that appears to be reversed by apolipoprotein-mediated phospholipid efflux is revealed and could represent a novel therapeutic approach to increasing macrophage cholesterol efflux and decreasing atherosclerosis.
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Comparison of triple-negative and estrogen receptor-positive/progesterone receptor-positive/HER2-negative breast carcinoma using quantitative fluorine-18 fluorodeoxyglucose/positron emission tomography imaging parameters: a potentially useful method for disease characterization.
Sandip Basu,Sandip Basu,Wengen Chen,Julia Tchou,Ayse Mavi,Ayse Mavi,Tevfik Cermik,Brian J. Czerniecki,Mitchell D. Schnall,Abass Alavi +9 more
TL;DR: In this article, the authors investigated the fluorine-18 fluorodeoxyglucose (FDG)-positron emission tomography (PET) imaging characteristics of triple-negative breast carcinoma and compared the results with characteristics of ER+/PR+/HER2− breast carcinomas, which usually carry a favorable prognosis.
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Functional imaging of inflammatory diseases using nuclear medicine techniques.
TL;DR: Functional imaging, led by FDG-PET imaging, is likely to play an increasingly critical role in assessing inflammatory disorders of known and unknown etiologies, and will improve their management immensely in the future.