W
Wenhui Jiang
Researcher at Medical University of South Carolina
Publications - 4
Citations - 566
Wenhui Jiang is an academic researcher from Medical University of South Carolina. The author has contributed to research in topics: Autophagy & Ceramide. The author has an hindex of 4, co-authored 4 publications receiving 475 citations.
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Journal ArticleDOI
Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy
R. David Sentelle,Can E. Senkal,Wenhui Jiang,Suriyan Ponnusamy,Salih Gencer,Shanmugam Panneer Selvam,Venkat K. Ramshesh,Yuri K. Peterson,John J. Lemasters,Zdzislaw M. Szulc,Jacek Bielawski,Besim Ogretmen +11 more
TL;DR: A novel receptor function of ceramide for anchoring LC3B-II-autophagolysosomes to mitochondrial membranes is suggested, defining a key mechanism for the induction of lethal mitophagy.
Journal ArticleDOI
Autophagy paradox and ceramide
Wenhui Jiang,Besim Ogretmen +1 more
TL;DR: This review focuses on recent studies with regard to the regulation of autophagy by Cer and elucidates the roles and mechanisms of action of Cer in controllingAutophagy paradox, as part of a Special Issue entitled New Frontiers in Sphingolipid Biology.
Journal ArticleDOI
Concerted functions of HDAC1 and microRNA-574-5p repress alternatively spliced ceramide synthase 1 expression in human cancer cells
Marisa Meyers-Needham,Suriyan Ponnusamy,Salih Gencer,Wenhui Jiang,Raquela J. Thomas,Can E. Senkal,Besim Ogretmen +6 more
TL;DR: Interference with HDAC1 and miR‐574‐5p reconstituted CerS1‐2 expression and C18‐ceramide generation in multiple human cancer cell lines, which subsequently inhibited proliferation and anchorage‐independent growth.
Journal ArticleDOI
Ceramide stress in survival versus lethal autophagy paradox: ceramide targets autophagosomes to mitochondria and induces lethal mitophagy.
Wenhui Jiang,Besim Ogretmen +1 more
TL;DR: In a recent study, characterization of novel mechanisms that regulate lethal autophagy revealed that C18-ceramide stress mediates LC3B-II-ceramides binding on mitochondrial membranes to target autophagosomes for mitophagy induction and tumor suppression.