C
Can E. Senkal
Researcher at Stony Brook University
Publications - 35
Citations - 3420
Can E. Senkal is an academic researcher from Stony Brook University. The author has contributed to research in topics: Ceramide & Ceramide synthase. The author has an hindex of 26, co-authored 34 publications receiving 2992 citations. Previous affiliations of Can E. Senkal include Medical University of South Carolina & Sewanee: The University of the South.
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Journal ArticleDOI
Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy
R. David Sentelle,Can E. Senkal,Wenhui Jiang,Suriyan Ponnusamy,Salih Gencer,Shanmugam Panneer Selvam,Venkat K. Ramshesh,Yuri K. Peterson,John J. Lemasters,Zdzislaw M. Szulc,Jacek Bielawski,Besim Ogretmen +11 more
TL;DR: A novel receptor function of ceramide for anchoring LC3B-II-autophagolysosomes to mitochondrial membranes is suggested, defining a key mechanism for the induction of lethal mitophagy.
Journal ArticleDOI
Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance.
Suriyan Ponnusamy,Marisa Meyers-Needham,Can E. Senkal,Sahar A. Saddoughi,David Sentelle,Shanmugam Panneer Selvam,Arelis Salas,Besim Ogretmen +7 more
TL;DR: Drawing conclusions of recent studies that describe opposing roles of de novo-generated ceramides by ceramide synthases and/or S1P in the regulation of cancer pathogenesis, as well as the development of sphingolipid-based cancer therapeutics and drug resistance are presented.
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Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis.
Sahar A. Saddoughi,Salih Gencer,Yuri K. Peterson,Katherine E. Ward,Archana Mukhopadhyay,Joshua J. Oaks,Jacek Bielawski,Zdzislaw M. Szulc,Raquela J. Thomas,Shanmugam Panneer Selvam,Can E. Senkal,Elizabeth Garrett-Mayer,Ryan M. De Palma,Dzmitry Fedarovich,Angen Liu,Amyn A. Habib,Amyn A. Habib,Robert V. Stahelin,Robert V. Stahelin,Danilo Perrotti,Besim Ogretmen +20 more
TL;DR: Data suggest that targeting I2PP2A/SET by FTY720 suppresses lung tumour growth, at least in part, via PP2A activation and necroptosis mediated by the kinase domain of RIPK1.
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Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways
TL;DR: Data reveal an unexpected and novel prosur‐vival role of CerS6/C16‐ceramide involved in the protection against ER‐stress‐induced apoptosis and induction of HNSCC tumor growth.
Journal ArticleDOI
Defects in Cell Growth Regulation by C18:0-Ceramide and Longevity Assurance Gene 1 in Human Head and Neck Squamous Cell Carcinomas *
Serap Koybasi,Can E. Senkal,Kamala P. Sundararaj,Stefka D. Spassieva,Jacek Bielawski,Walid Osta,Terry A. Day,James C. Jiang,S. Michal Jazwinski,Yusuf A. Hannun,Lina M. Obeid,Besim Ogretmen +11 more
TL;DR: A biological role for LAG1 and C18-ceramide in the regulation of growth of HNSCC is demonstrated, for the first time, in a liquid chromatography/mass spectroscopy study.