S
Salih Gencer
Researcher at Medical University of South Carolina
Publications - 23
Citations - 1244
Salih Gencer is an academic researcher from Medical University of South Carolina. The author has contributed to research in topics: Ceramide & Sphingolipid. The author has an hindex of 16, co-authored 23 publications receiving 1062 citations. Previous affiliations of Salih Gencer include İnönü University & Fatih University.
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Journal ArticleDOI
Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy
R. David Sentelle,Can E. Senkal,Wenhui Jiang,Suriyan Ponnusamy,Salih Gencer,Shanmugam Panneer Selvam,Venkat K. Ramshesh,Yuri K. Peterson,John J. Lemasters,Zdzislaw M. Szulc,Jacek Bielawski,Besim Ogretmen +11 more
TL;DR: A novel receptor function of ceramide for anchoring LC3B-II-autophagolysosomes to mitochondrial membranes is suggested, defining a key mechanism for the induction of lethal mitophagy.
Journal ArticleDOI
Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis.
Sahar A. Saddoughi,Salih Gencer,Yuri K. Peterson,Katherine E. Ward,Archana Mukhopadhyay,Joshua J. Oaks,Jacek Bielawski,Zdzislaw M. Szulc,Raquela J. Thomas,Shanmugam Panneer Selvam,Can E. Senkal,Elizabeth Garrett-Mayer,Ryan M. De Palma,Dzmitry Fedarovich,Angen Liu,Amyn A. Habib,Amyn A. Habib,Robert V. Stahelin,Robert V. Stahelin,Danilo Perrotti,Besim Ogretmen +20 more
TL;DR: Data suggest that targeting I2PP2A/SET by FTY720 suppresses lung tumour growth, at least in part, via PP2A activation and necroptosis mediated by the kinase domain of RIPK1.
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Targeting FLT3-ITD signaling mediates ceramide-dependent mitophagy and attenuates drug resistance in AML
Mohammed Dany,Salih Gencer,Rose Nganga,Raquela J. Thomas,Natalia V. Oleinik,Kyla D. Baron,Zdzislaw M. Szulc,Peter P. Ruvolo,Steven M. Kornblau,Michael Andreeff,Besim Ogretmen +10 more
TL;DR: The data reveal a novel mechanism which regulates AML cell death by ceramide-dependent mitophagy in response to FLT3-ITD targeting, attenuated by LCL-461, a mitochondria-targeted ceramide analog drug, in vivo.
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Production of l-asparaginase in Enterobacter aerogenes expressing Vitreoscilla hemoglobin for efficient oxygen uptake
Hikmet Geckil,Salih Gencer +1 more
TL;DR: It is shown that the Vitreoscilla hemoglobin expressing strain has from 10-fold to more than two orders of magnitude lower l-asparaginase activity than the wild type or the control without the vitreoscillas hemoglobin gene under different aeration conditions.
Journal ArticleDOI
TGF-β receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis.
Salih Gencer,Natalia V. Oleinik,Jisun Kim,Shanmugam Panneer Selvam,Ryan M. De Palma,Mohammed Dany,Rose Nganga,Raquela J. Thomas,Can E. Senkal,Philip H. Howe,Besim Ogretmen +10 more
TL;DR: A ceramide-dependent mechanism that suppresses cell migration and invasion by restricting TβRI/II-Shh signaling selectively at the plasma membrane of the primary cilium is revealed.