W
Wenjin Shi
Researcher at Hong Kong University of Science and Technology
Publications - 2
Citations - 40
Wenjin Shi is an academic researcher from Hong Kong University of Science and Technology. The author has contributed to research in topics: Regulation of gene expression & Histone H4. The author has an hindex of 1, co-authored 2 publications receiving 29 citations.
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Journal ArticleDOI
A novel histone H4 variant H4G regulates rDNA transcription in breast cancer.
Mengping Long,Xulun Sun,Wenjin Shi,An Yanru,Sophia T C Leung,Dongbo Ding,Manjinder S. Cheema,Nicol Macpherson,Christopher J. Nelson,Juan Ausió,Yan Yan,Toyotaka Ishibashi +11 more
TL;DR: It is found that modulating H4G expression affects rRNA expression levels, protein synthesis rates and cell-cycle progression, and the data suggest that H 4G expression alters nucleolar chromatin in a way that enhances rDNA transcription in breast cancer tissues.
Posted ContentDOI
A novel histone H4 variant regulates rDNA transcription in breast cancer
Mengping Long,Xulun Sun,Wenjin Shi,Yanru An,Tsz Chui Sophia Leung,Dongbo Ding,Manjinder S. Cheema,Nicol Macpherson,Christopher J. Nelson,Juan Ausió,Yan Yan,Toyotaka Ishibashi +11 more
TL;DR: H4G nucleolar localization increased rRNA levels, protein synthesis rates, and cell cycle progression, and micrococcal nuclease digestion of H4G-containing nucleosomes reconstituted in vitro indicated that H 4G destabilizes the nucleosome, which may serve to alter nucleolar chromatin in a way that enhances rDNA transcription in breast cancer tissues.