Y
Yan Yan
Researcher at Hong Kong University of Science and Technology
Publications - 22
Citations - 675
Yan Yan is an academic researcher from Hong Kong University of Science and Technology. The author has contributed to research in topics: Notch signaling pathway & Biology. The author has an hindex of 11, co-authored 17 publications receiving 557 citations. Previous affiliations of Yan Yan include University of Oregon & Princeton University.
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Journal ArticleDOI
The vacuolar proton pump (V-ATPase) is required for Notch signaling and endosomal trafficking in Drosophila
TL;DR: It is demonstrated that Rbcn-3 affects Notch signaling and trafficking through regulating V-ATPase function, which implies that the acidification of an intracellular compartment in the receiving cells is crucial for signaling.
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Structure of Crumbs tail in complex with the PALS1 PDZ-SH3-GK tandem reveals a highly specific assembly mechanism for the apical Crumbs complex.
TL;DR: It is discovered that the PDZ–SH3–GK tandem of PALS1 forms a structural supramodule interacting with the large part of the Crumbs tail with high affinity and specificity, supporting the apical–basal polarity of epithelial cells.
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Rabconnectin-3 Is a Functional Regulator of Mammalian Notch Signaling
TL;DR: Rabconnectin-3B knockdown phenocopied functional disruption of Notch signaling during osteoclast differentiation defines an important role for Rabconnectin3 and V-ATPase activity in the notch signaling pathway in mammalian cells.
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β-Spectrin regulates the hippo signaling pathway and modulates the basal actin network.
TL;DR: The abnormal stress fiber-like actin structure on the basal side of follicle cells provides a likely link between the β-spectrin mutations and the loss of the Hippo signaling activity phenotype.
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Apical constriction is driven by a pulsatile apical myosin network in delaminating Drosophila neuroblasts.
Yanru An,Guosheng Xue,Yang Shaobo,Deng Mingxi,Xiaowei Zhou,Weichuan Yu,Toyotaka Ishibashi,Lei Zhang,Yan Yan +8 more
TL;DR: It is demonstrated that a contractile actomyosin network across the apical cell surface is organized to drive apical constriction in delaminating neuroblasts, a conserved morphogenetic process important for the generation of cell diversity and maintenance of tissue homeostasis.